RGD Reference Report - Cholinesterase inhibitors exert a protective effect on endothelial damage in Alzheimer disease patients. - Rat Genome Database

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Cholinesterase inhibitors exert a protective effect on endothelial damage in Alzheimer disease patients.

Authors: Borroni, B  Agosti, C  Martini, G  Volpi, R  Brambilla, C  Caimi, L  Di Luca, M  Padovani, A 
Citation: Borroni B, etal., J Neurol Sci. 2005 Mar 15;229-230:211-3. Epub 2004 Dec 8.
RGD ID: 5685018
Pubmed: PMID:15760641   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jns.2004.11.030   (Journal Full-text)

It has been recently suggested that in Alzheimer disease (AD), the current available therapy with cholinesterase inhibitors (ChEIs) influences platelets amyloid precursor protein (APP) metabolism towards the nonamyloidogenic pathway. In order to investigate whether ChEIs may exert a protective role on vascular damage due to abeta deposition, several parameters of coagulation and fibrinolysis were assessed. Twenty patients with mild AD and 30 age-matched controls entered the study. All subjects performed a multidimensional neuropsychological assessment and a laboratory protocol. Individuals with vascular risk factors and systemic diseases were excluded. In mild AD patients, increased levels of markers of endothelial dysfunction, such as thrombomodulin (TM) and sE-selectin (sE-sel), were seen. After 1-month ChEIs treatment, a significant reduction of TM (p<0.05) and sE-sel (p<0.05) values towards the normal range was observed. These findings suggest that endothelial-related ChEIs action might contribute to the clinical efficacy in AD, slowing down pathology progression.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease  IEP 5685018protein:increased expression:bloodRGD 
Alzheimer's disease  ISOTHBD (Homo sapiens)5685018; 5685018 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Thbd  (thrombomodulin)

Genes (Mus musculus)
Thbd  (thrombomodulin)

Genes (Homo sapiens)
THBD  (thrombomodulin)


Additional Information