RGD Reference Report - The beta3-adrenoceptor agonist SR58611A ameliorates experimental colitis in rats. - Rat Genome Database

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The beta3-adrenoceptor agonist SR58611A ameliorates experimental colitis in rats.

Authors: Vasina, V  Abu-Gharbieh, E  Barbara, G  De Giorgio, R  Colucci, R  Blandizzi, C  Bernardini, N  Croci, T  Del Tacca, M  De Ponti, F 
Citation: Vasina V, etal., Neurogastroenterol Motil. 2008 Sep;20(9):1030-41. Epub 2008 May 15.
RGD ID: 5684890
Pubmed: PMID:18492028   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1365-2982.2008.01138.x   (Journal Full-text)

Beta(3)-adrenoceptor agonists protect against experimental gastric ulcers. We investigated the effects of the beta(3)-adrenoceptor agonist SR58611A on 2,4-dinitrobenzene sulphonic acid-induced colitis in rats and analysed the expression of beta(3)-adrenoceptors in the colonic wall. SR58611A was administered orally (1-10 mg kg(-1)) for 7 days, starting the day before induction of colitis. Colitis was assessed by macroscopic and histological scores, tissue myeloperoxidase activity, interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) levels. Reverse transcription-polymerase chain reaction and immunohistochemical analysis were used to examine the expression of beta(3)-adrenoceptors. SR58611A significantly reduced the severity of colitis as well as the tissue levels of TNF-alpha, IL-1beta and IL-6. Colitis was associated with a decreased expression of beta(3)-adrenoceptor mRNA in the mucosal/submucosal layer of distal colon and this reduction was not affected by SR58611A. Immunohistochemical analysis revealed beta(3)-adrenoceptors within the muscularis externa, in myenteric neurons and nerve fibres and in the submucosa. beta(3)-Adrenoceptor immunoreactivity was decreased in inflamed tissues compared to controls, particularly in the myenteric plexus; this reduction was counteracted by SR58611A. Amelioration of experimental colitis by the selective beta(3)-adrenoceptor agonist SR58611A suggests that beta(3)-adrenoceptors may represent a therapeutic target in gut inflammation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
colitis  ISOAdrb3 (Rattus norvegicus)5684890; 5684890mRNA:decreased expression:distal colon and mucosa (rat)RGD 
colitis  IEP 5684890mRNA:decreased expression:distal colon and mucosa (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adrb3  (adrenoceptor beta 3)

Genes (Mus musculus)
Adrb3  (adrenergic receptor, beta 3)

Genes (Homo sapiens)
ADRB3  (adrenoceptor beta 3)


Additional Information