RGD Reference Report - Positive correlation between Beta-3-Adrenergic Receptor (ADRB3) gene and gout in a Chinese male population. - Rat Genome Database

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Positive correlation between Beta-3-Adrenergic Receptor (ADRB3) gene and gout in a Chinese male population.

Authors: Wang, B  Meng, D  Wang, J  Jia, Z  Zhoub, S  Liu, S  Chu, N  Han, L  Zhang, K  Ma, X  Li, C 
Citation: Wang B, etal., J Rheumatol. 2011 Apr;38(4):738-40. Epub 2011 Feb 1.
RGD ID: 5684422
Pubmed: PMID:21285172   (View Abstract at PubMed)
DOI: DOI:10.3899/jrheum.101037   (Journal Full-text)

OBJECTIVE: The common polymorphism rs4994 [c. T387C, p. Trp64Arg (W64R)] of the lipolysis regulator beta-3-adrenergic receptor (ADRB3) was identified as a marker in the pathogenesis of hyperuricemia. As gout is characterized by elevated serum concentrations of uric acid, we investigated ADRB3 as a potential candidate for gout. METHODS: This was a prospective case-control study in a group of 421 male patients with gout and 312 gout-free male controls to genotype the single-nucleotide polymorphism rs4994 of ADRB3 gene. RESULTS: Our results showed that the C allele carrier confers a significantly higher risk for development of gout [chi-square = 4.91, df = 1, p = 0.027, OR 1.95 (adjusted by age, total cholesterol level, and body mass index), 95% CI 1.22-3.13 by dominant mode]. There was significantly higher uric acid level in carriers of the Arg64/Arg64 genotype in controls compared to non-carriers (480.5 mmol/l vs 315.0 mmol/l, respectively). CONCLUSION: ADRB3 rs4994 polymorphism is a potential candidate for the pathogenesis of gout in a male Chinese population.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
gout  IAGP 5684422DNA:missense mutation:cds:p.W64R rs4994 (human)RGD 
gout  ISOADRB3 (Homo sapiens)5684422; 5684422DNA:missense mutation:cds:p.W64R rs4994 (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Arthritis  IAGP 5684422DNA:missense mutation:cds:p.W64R (rs4994)RGD 
Hyperuricemia  IAGP 5684422DNA:missense mutation:cds:p.W64R (rs4994)RGD 
Objects Annotated

Genes (Rattus norvegicus)
Adrb3  (adrenoceptor beta 3)

Genes (Mus musculus)
Adrb3  (adrenergic receptor, beta 3)

Genes (Homo sapiens)
ADRB3  (adrenoceptor beta 3)


Additional Information