SIMULTANEOUS EVALUATION OF THE CIRCULATING LEVELS OF BOTH Th1 AND Th2 CHEMOKINES IN PATIENTS WITH AUTOIMMUNE ADDISON'S DISEASE.
Authors:
Bellastella, G Rotondi, M Pane, E Costantini, S Colella, C Calemma, R Capone, F Falorni, A Castello, G Sinisi, AA Bizzarro, A Chiovato, L Bellastella, A De Bellis, A
Citation:
Bellastella G, etal., J Endocrinol Invest. 2010 Dec 15.
Context: Chemokines play a key role in the recruitment of the immune cells into the autoimmune process; so, the simultaneous evaluation of circulating levels of Th1-related chemokines as CX chemokine ligand 10 (CXCL10) and macrophage inflammatory proteins 1alpha (CCL3/MIP-1alpha) and Th2- related chemokine, as macrophage inflammatory proteins 1 beta (CCL4/MIP-1beta) could be useful in the approach of some autoimmune diseases, including AAD. Objective: to evaluate plasmatic levels of MIP-1alpha, MIP-1beta, CXCL10 and adrenocortical antibodies in patients with AAD in treatment with corticosteroids. Patients and methods: Twelve women and 5 men (Group1) were divided in 2 subgroups: 9 with isolated AAD (Group 1a) and 8 associated with chronic autoimmune thyroiditis (Group 1b). MIP-1alpha, MIP-1beta and CXCL10 were evaluated in the serum of all patients and in 20 healthy controls, using a system for micro-array suspension. Results: The levels of MIP-1alpha, MIP-1beta and CXCL10 resulted significantly increased vs controls (p<0.001). An inverse significant correlation between the serum levels of MIP-1beta, and the duration of the disease was observed. Conclusion: High levels of MIP-1alpha and MIP-1beta associated with increased levels of CXCL10 in AAD seem to indicate a role of these chemokines in the autoimmune pathology of adrenal gland through the recruitment in loco of Th1 and Th2 cells. The simultaneous measurement of Th1-related chemokines (CXCL10 and MIP-1alpha) and of Th2- related chemokine MIP-1beta in the serum of patients with AAD would sustain a novel preliminary hypothesys on the immune microenvironment of chronic autoimmune inflammation within adrenal glands.
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