RGD Reference Report - Dietary plasma proteins attenuate the innate immunity response in a mouse model of acute lung injury. - Rat Genome Database

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Dietary plasma proteins attenuate the innate immunity response in a mouse model of acute lung injury.

Authors: Maijo, M  Miro, L  Polo, J  Campbell, J  Russell, L  Crenshaw, J  Weaver, E  Moreto, M  Perez-Bosque, A 
Citation: Maijo M, etal., Br J Nutr. 2011 Sep 12:1-9.
RGD ID: 5683874
Pubmed: PMID:21906407   (View Abstract at PubMed)
DOI: DOI:10.1017/S0007114511003655   (Journal Full-text)

We examined whether oral plasma protein supplements affect the innate immune response in a model of acute lung inflammation. Mice were fed diets supplemented with 8 % spray-dried plasma (SDP) or 2 % plasma Ig concentrate (IC) from day 19 (weaning) until day 34. The mice were challenged with intranasal lipopolysaccharide (LPS) at day 33 (and killed 24 h later for cytokine and leucocyte analyses) or at day 34 (and killed 6 h later for cytokine determinations). In bronchoalveolar lavage fluid (BALF), LPS increased the number of leucocytes by twenty-sevenfold, an effect that was partly prevented by both SDP and IC, and by twentyfold the percentage of activated monocytes, which was partly prevented by SDP. In the lung tissue, LPS increased the infiltrated leucocytes, and this effect was prevented in part by SDP. In unchallenged mice, both SDP and IC diets reduced the percentage of resident neutrophils and monocytes (P < 0.05). In the blood, both SDP and IC completely prevented LPS-dependent monocyte activation (CD14+; P < 0.05). LPS dramatically increased the concentration of cytokines (TNF-alpha, IL-1alpha, IL-6, granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor) and chemokines (CXCL1, CCL2, CCL3 and CCL4) in BALF. The acute response of cytokine production was reduced by 20-80 % by both SDP and IC. For chemokines, plasma supplements had no effect on LPS-induced CXCL1 expression but significantly reduced CCL2, CCL3 and CCL4 production (P < 0.05). The results support the view that dietary plasma proteins can be used to attenuate endotoxin-associated lung inflammation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Acute Lung Injury  ISOCcl4 (Mus musculus)5683874; 5683874protein:increased expression:respiratory system fluid/secretion RGD 
Acute Lung Injury  IEP 5683874protein:increased expression:respiratory system fluid/secretion RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl4  (C-C motif chemokine ligand 4)

Genes (Mus musculus)
Ccl4  (C-C motif chemokine ligand 4)

Genes (Homo sapiens)
CCL4  (C-C motif chemokine ligand 4)


Additional Information