RGD Reference Report - Specificity of fusion genes in adipocytic tumors. - Rat Genome Database

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Specificity of fusion genes in adipocytic tumors.

Authors: Kubo, T  Matsui, Y  Naka, N  Araki, N  Myoui, A  Endo, K  Yasui, N  Ohtani, O  Suzuki, K  Kimura, T  Yoshikawa, H  Ueda, T 
Citation: Kubo T, etal., Anticancer Res. 2010 Feb;30(2):661-4.
RGD ID: 5509913
Pubmed: PMID:20332486   (View Abstract at PubMed)

BACKGROUND: In subsets of adipocytic tumors, specific chromosomal translocations lead to the generation of fusion genes. The high mobility group A2 (HMGA2)-lipoma preferred partner (LPP) and the reciprocal LPP-HMGA2 represent such fusion genes in lipoma, while the human translocation liposarcoma (TLS)-CCAAT/enhancer binding protein (C/EBP) homologous protein (CHOP) and the Ewing sarcoma (EWS)-CHOP in liposarcoma. However, the specificity of these fusion genes has not been established in a variety of adipocytic tumors. PATIENTS AND METHODS: One hundred and seventy-two cases of adipocytic tumors, comprising 98 cases of lipoma and 74 cases of liposarcoma, were analyzed for the possible expression of HMGA2-LPP, LPP-HMGA2, TLS-CHOP and EWS-CHOP fusion genes, using a reverse-transcription polymerase chain reaction method. RESULTS: In lipoma, twenty-two cases (22.4%) were associated with either HMGA2-LPP or LPP-HMGA2, while neither TLS-CHOP nor EWS-CHOP transcript was detectable. On the contrary, in liposarcoma, neither HMGA2-LPP nor LPP-HMGA2 transcript was detectable, although twenty-five cases (33.8%) were related to either TLS-CHOP or EWS-CHOP. CONCLUSION: HMGA2-LPP and LPP-HMGA2 were specific to lipoma, and TLS-CHOP and EWS-CHOP were specific to liposarcoma.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
liposarcoma  IAGP 5509913 RGD 
liposarcoma  ISOFUS (Homo sapiens)5509913; 5509913 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fus  (Fus RNA binding protein)

Genes (Mus musculus)
Fus  (fused in sarcoma)

Genes (Homo sapiens)
FUS  (FUS RNA binding protein)


Additional Information