RGD Reference Report - Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase. - Rat Genome Database

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Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase.

Authors: Emerson, MR  LeVine, SM 
Citation: Emerson MR and LeVine SM, Brain Res. 2004 Sep 17;1021(1):140-5.
RGD ID: 5509618
Pubmed: PMID:15328042   (View Abstract at PubMed)
DOI: DOI:10.1016/j.brainres.2004.06.045   (Journal Full-text)

12/15-Lipoxygenase (12/15-LO) produces 15-hydroxyeicosatetraenoic acid (15-HETE) and 13-hydroxyoctadecadienoic acid (13-HODE) which are agonists for peroxisome proliferator-activated receptor-gamma (PPARgamma). PPARgamma agonists reduce clinical severity of experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis. In contrast, 5-lipoxygenase (5-LO) produces the generally proinflammatory leukotrienes (LTs) which would be expected to worsen EAE. We tested the hypotheses that EAE severity would be exacerbated in 12/15-LO-deficient mice and attenuated in 5-LO-deficient mice. 12/15-LO deficiency conferred a significantly worse disease course, and surprisingly, 5-LO deficiency also caused significantly more severe EAE compared to control mice. These data suggest that PPARgamma-regulated gene expression and that 5-LO production of certain LTs have the ability to diminish EAE. Continued analysis will provide insight into the endogenous LO-generated effectors that assist in tempering EAE.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Autoimmune Encephalomyelitis  ISOAlox15 (Mus musculus)5509618; 5509618 RGD 
Experimental Autoimmune Encephalomyelitis  IMP 5509618 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Alox15  (arachidonate 15-lipoxygenase)

Genes (Mus musculus)
Alox15  (arachidonate 15-lipoxygenase)

Genes (Homo sapiens)
ALOX15  (arachidonate 15-lipoxygenase)


Additional Information