RGD Reference Report - Elevated serum S100B levels in acute spinal fracture without head injury. - Rat Genome Database

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Elevated serum S100B levels in acute spinal fracture without head injury.

Authors: Lee, SJ  Kim, CW  Lee, KJ  Choe, JW  Kim, SE  Oh, JH  Park, YS 
Citation: Lee SJ, etal., Emerg Med J. 2010 Mar;27(3):209-12.
RGD ID: 5508786
Pubmed: PMID:20304889   (View Abstract at PubMed)
DOI: DOI:10.1136/emj.2008.063743   (Journal Full-text)

BACKGROUND: S100B is a biomarker that reflects injury to the central nervous system. As the spine is an integral part of the spinal cord, a study was undertaken to investigate whether serum S100B levels are associated with acute spinal fracture without head injury. METHODS: The study population consisted of 32 consecutive patients aged > or = 18 years in whom the emergency physicians suspected spinal fractures. All the patients underwent CT scans to establish the diagnosis of spinal fracture. MRI was then performed on all the patients to determine the presence of spinal cord injury. RESULTS: Serum S100B levels were higher in the spinal fracture group than in the non-spinal fracture group, and 19 of the 20 patients in the spinal fracture group (95%) had an S100B level >0.12 microg/l, whereas all 12 of the non-spinal fracture group had an S100B level < or = 0.12 microg/l. The S100B level in patients with epidural encroachment of the spinal cord was significantly higher (0.22-4.58 microg/l; mean 2.45 microg/l; 95% CI 0.95 to 3.94) than in those without epidural encroachment (0.114-2.87 microg/l; mean 0.80 microg/l; 95% CI 0.24 to 1.37) (p=0.037). Plain radiography revealed no definite abnormal findings in half of the patients with spinal fracture. CONCLUSIONS: Serum S100B levels are raised in all patients with acute spinal fracture without head injury. Spinal fracture may therefore be one of the extracerebral sources of S100B. Serum S100B levels may be an effective tool for excluding subtle spinal fractures with no clear radiographic findings.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Spinal Fractures  IEP 5508786protein:increased expression:serumRGD 
Spinal Fractures  ISOS100B (Homo sapiens)5508786; 5508786protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
S100b  (S100 calcium binding protein B)

Genes (Mus musculus)
S100b  (S100 protein, beta polypeptide, neural)

Genes (Homo sapiens)
S100B  (S100 calcium binding protein B)


Additional Information