RGD Reference Report - Increased serum S-100B and neuron specific enolase - Potential markers of early nervous system involvement in essential hypertension. - Rat Genome Database

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Increased serum S-100B and neuron specific enolase - Potential markers of early nervous system involvement in essential hypertension.

Authors: Gonzalez-Quevedo, A  Garcia, SG  Concepcion, OF  Freixas, RS  Sotolongo, LQ  Menendez, MC  Sanchez, MP  Almirall, IF  Carriera, RF  Diaz, ZH  Menendez, K 
Citation: Gonzalez-Quevedo A, etal., Clin Biochem. 2011 Feb;44(2-3):154-9. Epub 2010 Dec 1.
RGD ID: 5508770
Pubmed: PMID:21130083   (View Abstract at PubMed)
DOI: DOI:10.1016/j.clinbiochem.2010.11.006   (Journal Full-text)

OBJECTIVES: To investigate the occurrence of subclinical neurologic involvement in patients with essential hypertension employing serum biochemical markers. DESIGN AND METHODS: Fifty patients with essential hypertension and 42 controls with no clinical evidence of neurological disease were recruited. Serum S100B protein and neuron specific enolase (NSE) were determined by employing immunoassay kits from CanAg Diagnostics AB (Sweden). Brain MRI and fundoscopic exploration were conducted. RESULTS: S-100B and NSE levels were significantly higher in hypertensive patients than in controls. In hypertensive patients, multivariate analysis revealed that NSE was independently associated with two variables expressing severity of hypertension: diastolic blood pressure and grade of retinopathy. Brain MRI studies demonstrated higher NSE levels in patients with more severe white matter lesions. CONCLUSIONS: Raised NSE levels are associated with a higher severity of hypertension and of white matter lesions, providing preliminary evidence that suggests the presence of silent brain damage in a subset of hypertensive patients.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension severityIEP 5508770protein:increased expression:serumRGD 
hypertension severityISOENO2 (Homo sapiens)5508770; 5508770protein:increased expression:serumRGD 
hypertension  IEP 5508770protein:increased expression:serumRGD 
hypertension  ISOS100B (Homo sapiens)5508770; 5508770protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Eno2  (enolase 2)
S100b  (S100 calcium binding protein B)

Genes (Mus musculus)
Eno2  (enolase 2, gamma neuronal)
S100b  (S100 protein, beta polypeptide, neural)

Genes (Homo sapiens)
ENO2  (enolase 2)
S100B  (S100 calcium binding protein B)


Additional Information