RGD Reference Report - GSTM1, GSTP1, prenatal smoke exposure, and atopic dermatitis. - Rat Genome Database

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GSTM1, GSTP1, prenatal smoke exposure, and atopic dermatitis.

Authors: Wang, IJ  Guo, YL  Lin, TJ  Chen, PC  Wu, YN 
Citation: Wang IJ, etal., Ann Allergy Asthma Immunol. 2010 Aug;105(2):124-9. Epub 2010 Jun 11.
RGD ID: 5490981
Pubmed: PMID:20674822   (View Abstract at PubMed)
DOI: DOI:10.1016/j.anai.2010.04.017   (Journal Full-text)

BACKGROUND: The increase in the prevalence of atopic dermatitis (AD) is likely to involve changes in specific environmental exposures among genetically susceptible individuals. OBJECTIVE: To evaluate the effect of glutathione S-transferase (GST) genotype polymorphisms and prenatal smoke exposure on pediatric AD on the basis of the cord blood cotinine levels. METHODS: We conducted a case-control study composed of 34 children with AD and 106 non-AD controls, all of whom were selected from 483 participants in the Taiwan Birth Panel cohort study. Cord blood samples and information on perinatal factors of children were gathered at birth. At 2 years of age, information about the development of AD and environmental exposures was collected. We compared AD with non-AD children for GTM1 and GSTP1 polymorphisms stratified by the cotinine level. Multiple logistic regressions were performed to estimate the association of genotype polymorphisms and cotinine levels with AD. RESULTS: GSTM1 null and GSTP1 Ile/Ile genotypes showed a significant increase in the risk of AD (odds ratio [OR], 3.61; 95% confidence interval [CI], 1.40-9.31; and OR, 3.11; 95% CI, 1.30-7.46; respectively). In children with a cotinine level less than 0.1 ng/mL, the risk of AD increased for those carrying 2 GSTP1 Ile-105 alleles (OR, 6.63; 95% CI, 1.46-30.18). In children a with cotinine level of 0.1 ng/mL or greater, the GSTM1 null genotype was significantly related to AD (OR, 5.21; 95% CI, 1.32-20.58). CONCLUSIONS: Within groups of children, genetic polymorphisms in GSTM1 and GSTP1 may be responsible for differences in susceptibility to AD with regard to prenatal smoke exposure.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
atopic dermatitis  IAGP 5490981DNA:deletion: :RGD 
atopic dermatitis  IAGP 5490981DNA:polymorphism:exon:p.I105V (rs1695) (human) RGD 
atopic dermatitis  ISOGSTM1 (Homo sapiens)5490981; 5490981DNA:deletion: :RGD 
atopic dermatitis  ISOGSTP1 (Homo sapiens)5490981; 5490981DNA:polymorphism:exon:p.I105V (rs1695) (human) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gstm1  (glutathione S-transferase mu 1)
Gstp1  (glutathione S-transferase pi 1)

Genes (Mus musculus)
Gstm1  (glutathione S-transferase, mu 1)
Gstp1  (glutathione S-transferase, pi 1)

Genes (Homo sapiens)
GSTM1  (glutathione S-transferase mu 1)
GSTP1  (glutathione S-transferase pi 1)


Additional Information