RGD Reference Report - Greatly attenuated experimental autoimmune encephalomyelitis in aquaporin-4 knockout mice. - Rat Genome Database

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Greatly attenuated experimental autoimmune encephalomyelitis in aquaporin-4 knockout mice.

Authors: Li, L  Zhang, H  Verkman, AS 
Citation: Li L, etal., BMC Neurosci. 2009 Aug 6;10:94.
RGD ID: 5490116
Pubmed: PMID:19660138   (View Abstract at PubMed)
PMCID: PMC3152780   (View Article at PubMed Central)
DOI: DOI:10.1186/1471-2202-10-94   (Journal Full-text)

BACKGROUND: The involvement of astrocyte water channel aquaporin-4 (AQP4) in autoimmune diseases of the central nervous system has been suggested following the identification of AQP4 autoantibodies in neuromyelitis optica, an inflammatory demyelinating disease. RESULTS: We investigated the involvement of AQP4 in disease severity in an established mouse model of experimental autoimmune encephalomyelitis (EAE) produced by immunization with myelin oligodendrocyte glycoprotein (MOG 35-55) peptide. EAE was remarkably attenuated in AQP4 null mice compared to identically treated wildtype mice. Whereas most wildtype mice developed progressive tail and hindlimb paralysis, clinical signs were virtually absent in AQP4 null mice. Brain and spinal cords from AQP1 null mice showed greatly reduced mononuclear cell infiltration compared to wildtype mice, with relatively little myelin loss and axonal degeneration. CONCLUSION: The reduced severity of autoimmune encephalomyelitis in AQP4 deficiency suggests AQP4 as a novel determinant in autoimmune inflammatory diseases of the central nervous system and hence a potential drug target.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Autoimmune Encephalomyelitis severityISOAqp4 (Mus musculus)5490116; 5490116 RGD 
Experimental Autoimmune Encephalomyelitis severityIMP 5490116 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Aqp4  (aquaporin 4)

Genes (Mus musculus)
Aqp4  (aquaporin 4)

Genes (Homo sapiens)
AQP4  (aquaporin 4)


Additional Information