RGD Reference Report - Clinical, serologic, and immunogenetic features of familial idiopathic inflammatory myopathy. - Rat Genome Database

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Clinical, serologic, and immunogenetic features of familial idiopathic inflammatory myopathy.

Authors: Rider, LG  Gurley, RC  Pandey, JP  Garcia de la Torre, I  Kalovidouris, AE  O'Hanlon, TP  Love, LA  Hennekam, RC  Baumbach, LL  Neville, HE  Garcia, CA  Klingman, J  Gibbs, M  Weisman, MH  Targoff, IN  Miller, FW 
Citation: Rider LG, etal., Arthritis Rheum. 1998 Apr;41(4):710-9.
RGD ID: 5147869
Pubmed: PMID:9550481   (View Abstract at PubMed)
DOI: DOI:10.1002/1529-0131(199804)41:4<710::AID-ART19>3.0.CO;2-K   (Journal Full-text)

OBJECTIVE: To describe the clinical, serologic, and immunogenetic features of familial idiopathic inflammatory myopathy (IIM) and to compare these with the features of sporadic IIM. METHODS: Clinical signs and symptoms, autoantibodies, HLA-DRB1 and DQA1 alleles, and GM/KM phenotypes were compared among 36 affected and 28 unaffected members of 16 unrelated families in which 2 or more blood relatives developed an IIM. In addition, findings in patients with familial IIM were compared with those in 181 patients with sporadic IIM. The families included 3 pairs of monozygotic twins with juvenile dermatomyositis, 11 families with other siblings or relatives with polymyositis or dermatomyositis, and 2 families with inclusion body myositis. RESULTS: The clinical features of familial IIM were similar to those of sporadic IIM, although the frequency of myositis-specific autoantibodies was lower in familial than in sporadic IIM. DRB1*0301 was a common genetic risk factor for familial and sporadic IIM, but contributed less to the genetic risk of familial IIM (etiologic fraction 0.35 versus 0.51 in sporadic IIM). Homozygosity at the HLA-DQA1 locus was found to be a genetic risk factor unique to familial IIM (57% versus 24% of controls; odds ratio 4.2, corrected P = 0.002). CONCLUSION: These findings emphasize that 1) familial muscle weakness is not always due to inherited metabolic defects or dystrophies, but may be the result of the development of IIM in several members of the same family, and 2) multiple genetic factors are likely important in the etiology and disease expression of familial IIM, as is also the case for sporadic myositis, but DQA1 homozygosity is a distinct risk factor for familial IIM.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
myositis susceptibilityISOHLA-DQA1 (Homo sapiens)5147869; 5147869DNA:polymorphisms:multipleRGD 
myositis susceptibilityIAGP 5147869DNA:polymorphisms:multipleRGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Myositis susceptibilityIAGP 5147869DNA:polymorphisms:multipleRGD 
Objects Annotated

Genes (Rattus norvegicus)
RT1-Ba  (RT1 class II, locus Ba)

Genes (Mus musculus)
H2-Aa  (histocompatibility 2, class II antigen A, alpha)

Genes (Homo sapiens)
HLA-DQA1  (major histocompatibility complex, class II, DQ alpha 1)


Additional Information