RGD Reference Report - [HLA-DQ molecules associated with myasthenia gravis in Chinese patients]. - Rat Genome Database

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[HLA-DQ molecules associated with myasthenia gravis in Chinese patients].

Authors: Li, X  Zhang, KX  Fan, YX  Chen, XZ  Zuo, J  Pan, XH  Zhu, DL  Geng, ZC 
Citation: Li X, etal., Yi Chuan Xue Bao. 1999;26(4):295-300.
RGD ID: 5147855
Pubmed: PMID:10593018   (View Abstract at PubMed)

Myasthenia Gravis (MG) is an autoimmune disease which is a neuromuscular disorder of autoimmune origin. MG in different races or ethnic groups has different genetic susceptibility. To search for the associations of MG in the Chinese patients with HLA-DQ molecules, PCR-RFLP method was employed for genotyping HLA-DQA1 and -DQB1 genes of MG patients and the normal Chinese. The distributions of alleles of DQA1 and DQB1 in the normal Chinese and the MG patients were listed. The DQB allele, DQB1 * 0302 was positively associated with MG (RR = 2.990, Pc = 0.0307), and a negative association was found for DQA1 * 0501 (RR = 0.4166, Pc = 0.0315). DQ haplotype DQA1 * 0301-DQB1 * 0302 was significantly increased in patients when compared to controls (RR = 7.727, Pc = 0.0109).

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
myasthenia gravis  ISOHLA-DQA1 (Homo sapiens)5147855; 5147855DNA:polymorphisms more ...RGD 
myasthenia gravis  ISOHLA-DQB1 (Homo sapiens)5147855; 5147855DNA:polymorphism and haplotype:cds:HLA-DQB1*0302 (human)RGD 
myasthenia gravis  IAGP 5147855DNA:polymorphisms more ...RGD 
myasthenia gravis  IAGP 5147855DNA:polymorphism and haplotype:cds:HLA-DQB1*0302 (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Fatigable weakness  IAGP 5147855DNA:polymorphisms more ...RGD 
Fatigable weakness  IAGP 5147855DNA:polymorphism and haplotype:cds:HLA-DQB1*0302RGD 
Objects Annotated

Genes (Rattus norvegicus)
RT1-Ba  (RT1 class II, locus Ba)
RT1-Bb  (RT1 class II, locus Bb)

Genes (Mus musculus)
H2-Aa  (histocompatibility 2, class II antigen A, alpha)
H2-Ab1  (histocompatibility 2, class II antigen A, beta 1)

Genes (Homo sapiens)
HLA-DQA1  (major histocompatibility complex, class II, DQ alpha 1)
HLA-DQB1  (major histocompatibility complex, class II, DQ beta 1)


Additional Information