RGD Reference Report - [Association between asthma and the polymorphism of HLA-DQ genes]. - Rat Genome Database

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[Association between asthma and the polymorphism of HLA-DQ genes].

Authors: Guo, X  Ni, P  Li, L 
Citation: Guo X, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2001 Mar;24(3):139-41.
RGD ID: 5147831
Pubmed: PMID:11802952   (View Abstract at PubMed)

OBJECTIVE: To investigate association between asthma and HLA-DQ genes in Chinese asthma family. METHODS: HLA genotyping was done for HLA-DQ using polymerase chain reaction-sequence specific primers (PCR-SSP) in 98 members of 32 Chinese asthma families and 67 normal controls. RESULTS: The allele frequencies of DQA1 * 0101 and DQA1 * 0601 in asthmatics (40.0% and 45.0% respectively) were significantly higher than those in normal controls (16.4% and 13.4% respectively; chi(2) = 6.1860, P < 0.05, RR = 3.39 and chi(2) = 11.609 0, P < 0.01, RR = 5.27 respectively). The allele frequencies of DQB1 * 0303 and DQB1 * 0601 in asthmatics (55.0% and 47.5% respectively) were also significantly higher than those in normal controls (13.7% and 13.7% respectively; chi(2) = 15.740 0, P < 0.01, RR = 7.68 and chi(2) = 10.930 0, P < 0.01, RR = 5.69 respectively). The allele frequency of DQ * 0201 (39.4%) was significantly higher in members with positive specific IgE response to dermatophagoides than that in non-atopy members (12.0%) in asthma family (t = 2.382 5, P < 0.05). CONCLUSION: HLA-DQA1* 0101, DQA1 * 0601 and HLA-DQB1 * 0303, DQB1 * 0601 may be the susceptible alleles of asthma. HLA-DQB1 * 0201 allele may limit the specific IgE response to dermatophagoides.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
asthma  ISOHLA-DQA1 (Homo sapiens)5147831; 5147831DNA:polymorphisms (human)RGD 
asthma  ISOHLA-DQB1 (Homo sapiens)5147831; 5147831DNA:polymorphisms (human)RGD 
asthma  IAGP 5147831; 5147831DNA:polymorphisms (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-Ba  (RT1 class II, locus Ba)
RT1-Bb  (RT1 class II, locus Bb)

Genes (Mus musculus)
H2-Aa  (histocompatibility 2, class II antigen A, alpha)
H2-Ab1  (histocompatibility 2, class II antigen A, beta 1)

Genes (Homo sapiens)
HLA-DQA1  (major histocompatibility complex, class II, DQ alpha 1)
HLA-DQB1  (major histocompatibility complex, class II, DQ beta 1)


Additional Information