RGD Reference Report - Elevated expression of Tim-3 on CD8 T cells correlates with disease severity of pulmonary tuberculosis. - Rat Genome Database

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Elevated expression of Tim-3 on CD8 T cells correlates with disease severity of pulmonary tuberculosis.

Authors: Wang, X  Cao, Z  Jiang, J  Li, Y  Dong, M  Ostrowski, M  Cheng, X 
Citation: Wang X, etal., J Infect. 2011 Apr;62(4):292-300. Epub 2011 Mar 5.
RGD ID: 5135524
Pubmed: PMID:21382414   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jinf.2011.02.013   (Journal Full-text)

OBJECTIVES: T cell immunoglobulin and mucin domain-containing molecule 3 (Tim-3) plays an important role in regulating T cell responses and induction of peripheral tolerance. In this study, the association of Tim-3 with active pulmonary tuberculosis (TB) was investigated. METHODS: Tim-3 expression on CD8 T cells and its influence on production of effector molecules and proliferation of CD8 T cells were examined. RESULTS: Pulmonary TB patients had significantly elevated Tim-3 expression on total CD8 T cells (P < 0.0001) and on antigen-specific CD8 T cells (P = 0.0028) compared with tuberculin-positive healthy controls. The expression of Tim-3 on CD8 T cells was significantly higher in smear/culture-positive TB patients than smear/culture-negative TB patients (P < 0.0001). Tim-3 expressing CD8 T cells had reduced production of IFN-gamma, decreased degranulation and lower proliferation in response to Mycobacterium tuberculosis antigen stimulation. Blocking of Tim-3 signaling led to significantly increased production of IFN-gamma. CONCLUSIONS: The elevated expression of Tim-3 on CD8 T cells correlates with functional defects of CD8 T cells and disease severity of pulmonary TB.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pulmonary tuberculosis  IEP 5135524 RGD 
pulmonary tuberculosis  ISOHAVCR2 (Homo sapiens)5135524; 5135524 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Havcr2  (hepatitis A virus cellular receptor 2)

Genes (Mus musculus)
Havcr2  (hepatitis A virus cellular receptor 2)

Genes (Homo sapiens)
HAVCR2  (hepatitis A virus cellular receptor 2)


Additional Information