RGD Reference Report - Bronchial mucosal inflammation and upregulation of CXC chemoattractants and receptors in severe exacerbations of asthma. - Rat Genome Database

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Bronchial mucosal inflammation and upregulation of CXC chemoattractants and receptors in severe exacerbations of asthma.

Authors: Qiu, Y  Zhu, J  Bandi, V  Guntupalli, KK  Jeffery, PK 
Citation: Qiu Y, etal., Thorax. 2007 Jun;62(6):475-82. Epub 2007 Jan 18.
RGD ID: 5135243
Pubmed: PMID:17234659   (View Abstract at PubMed)
PMCID: PMC2117215   (View Article at PubMed Central)
DOI: DOI:10.1136/thx.2006.066670   (Journal Full-text)

BACKGROUND: A study was undertaken to test the hypothesis that severe exacerbations of asthma are characterised by increased bronchial mucosal neutrophilia associated with upregulation of neutrophil chemoattractant ligands and their specific cell surface receptors. METHODS: Immunohistology and in situ hybridisation were applied to endobronchial biopsy specimens from three groups: (1) 15 patients admitted to hospital with a severe exacerbation of asthma (E-asthma), (2) 15 with stable asthma (S-asthma) and (3) 15 non-atopic and non-smoker surgical controls (NSC). RESULTS: There were significantly more neutrophils and eosinophils in the epithelium and subepithelium of patients in the E-asthma group (median (range) neutrophils 7 (0-380) and 78 (10-898)/mm2, eosinophils 31 (0-167) and 60 (6-351)/mm2, p

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
asthma  IEP 5135243mRNA:increased expression:bronchus epitheliumRGD 
asthma  ISOCXCL6 (Homo sapiens)5135243; 5135243mRNA:increased expression:bronchus epitheliumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cxcl6  (C-X-C motif chemokine ligand 6)

Genes (Mus musculus)
Cxcl5  (C-X-C motif chemokine ligand 5)

Genes (Homo sapiens)
CXCL5  (C-X-C motif chemokine ligand 5)


Additional Information