RGD Reference Report - Role of Akt-dependent up-regulation of hemeoxygenase-1 in resveratrol-mediated attenuation of hepatic injury after trauma hemorrhage. - Rat Genome Database

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Role of Akt-dependent up-regulation of hemeoxygenase-1 in resveratrol-mediated attenuation of hepatic injury after trauma hemorrhage.

Authors: Yu, HP  Yang, SC  Lau, YT  Hwang, TL 
Citation: Yu HP, etal., Surgery. 2010 Jul;148(1):103-9. Epub 2010 Feb 1.
RGD ID: 5135001
Pubmed: PMID:20117814   (View Abstract at PubMed)
DOI: DOI:10.1016/j.surg.2009.12.008   (Journal Full-text)

BACKGROUND: Protein kinase B (Akt) is known to be involved in pro-inflammatory and chemotactic events in response to injury. Akt activation also leads to the induction of hemeoxygenase (HO)-1, which exerts potent anti-inflammatory effects. The aim of this study is to elucidate whether Akt/HO-1 plays any role in resveratrol-mediated attenuation of hepatic injury after trauma hemorrhage. METHODS: Male Sprague-Dawley rats were subjected to trauma hemorrhage. A single dose of resveratrol (30-mg/kg body weight) with or without a PI3 K inhibitor (wortmannin) or an HO antagonist (chromium-mesoporphyrin) was administered intravenously during resuscitation. Various parameters were measured at 24 hours postresuscitation. RESULTS: Results showed that trauma hemorrhage increased hepatic myeloperoxidase activity, cytokine-induced neutrophil chemoattractant (CINC)-1, CINC-3, intercellular adhesion molecule-1, and interleukin-6 levels and plasma aspartate and alanine aminotransferases concentrations. These parameters were significantly improved in the resveratrol-treated rats subjected to trauma hemorrhage. Resveratrol treatment also increased hepatic Akt activation and HO-1 expression as compared with vehicle-treated trauma hemorrhaged rats. Coadministration of wortmannin or chromium-mesoporphyrin prevented the beneficial effects of resveratrol administration on postresuscitation proinflammatory responses and hepatic injury. CONCLUSION: These findings collectively suggest that the salutary effects of resveratrol administration on attenuation of hepatic injury after trauma hemorrhage are likely mediated via up-regulation of Akt-dependent HO-1 expression.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Hemorrhage  ISOCxcl1 (Rattus norvegicus)5135001; 5135001associated with Wounds and PenetratingRGD 
Hemorrhage  IEP 5135001associated with Wounds and PenetratingRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cxcl1  (C-X-C motif chemokine ligand 1)

Genes (Mus musculus)
Cxcl1  (C-X-C motif chemokine ligand 1)

Genes (Homo sapiens)
CXCL1  (C-X-C motif chemokine ligand 1)


Additional Information