RGD Reference Report - Anti-angiogenic and anti-inflammatory effects of SERPINA3K on corneal injury. - Rat Genome Database

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Anti-angiogenic and anti-inflammatory effects of SERPINA3K on corneal injury.

Authors: Liu, Xiaochen  Lin, Zhirong  Zhou, Tong  Zong, Ronrong  He, Hui  Liu, Zhen  Ma, Jian-xing  Liu, Zuguo  Zhou, Yueping 
Citation: Liu X, etal., PLoS One. 2011 Jan 31;6(1):e16712. doi: 10.1371/journal.pone.0016712.
RGD ID: 5131478
Pubmed: PMID:21304961   (View Abstract at PubMed)
PMCID: PMC3031620   (View Article at PubMed Central)
DOI: DOI:10.1371/journal.pone.0016712   (Journal Full-text)

SERPINA3K is a member of the serine proteinase inhibitor (SERPIN) family. Here we evaluated the therapeutic effects of SERPINA3K on neovascularization and inflammation in a rat cornea alkali burn model that is commonly employed to study corneal wounding. Topical treatment of the injured rat cornea with SERPINA3K (20 µg/eye/day) for 7 days significantly decreased the neovascular area, compared with the groups treated with BSA or PBS. The SERPINA3K treatment also ameliorated the corneal inflammation as evaluated by the inflammatory index. Furthermore, SERPINA3K enhanced the recovery of corneal epithelium after the alkali injury. Toward the mechanism of action, SERPINA3K down-regulated the expression of the pro-angiogenic and pro-inflammatory factors, vascular endothelial growth factor and tumor necrosis factor-a and up-regulated the expression of the anti-angiogenic factor, pigment epithelium-derived factor. SERPINA3K specifically inhibited growth of vascular endothelial cells. Meanwhile, SERPINA3K significantly up-regulated the expression of EGFR in the corneal epithelium. These findings suggest that SERPINA3K has therapeutic potential for corneal inflammation and NV.

Objects referenced in this article
Gene Egfr epidermal growth factor receptor Rattus norvegicus

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