RGD Reference Report - Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-kappaB and EGFR pathways. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-kappaB and EGFR pathways.

Authors: Hewson, CA  Haas, JJ  Bartlett, NW  Message, SD  Laza-Stanca, V  Kebadze, T  Caramori, G  Zhu, J  Edbrooke, MR  Stanciu, LA  Kon, OM  Papi, A  Jeffery, PK  Edwards, MR  Johnston, SL 
Citation: Hewson CA, etal., Eur Respir J. 2010 Dec;36(6):1425-35. Epub 2010 Jun 4.
RGD ID: 5131431
Pubmed: PMID:20525715   (View Abstract at PubMed)
DOI: DOI:10.1183/09031936.00026910   (Journal Full-text)

Rhinovirus (RV) infections are the major cause of asthma exacerbations, the major cause of morbidity and mortality in asthma. MUC5AC is the major mucin produced by bronchial epithelial cells. Whether RV infection upregulates MUC5AC in vivo is unknown and the molecular mechanisms involved are incompletely understood. We investigated RV induction of MUC5AC in vivo and in vitro to identify targets for development of new therapies for asthma exacerbations. RV infection increased MUC5AC release in normal and asthmatic volunteers experimentally infected with RV-16, and in asthmatic, but not normal, subjects, this was related to virus load. Bronchial epithelial cells were confirmed a source of MUC5AC in vivo. RV induction of MUC5AC in bronchial epithelial cells in vitro occurred via nuclear factor-kappaB-dependent induction of matrix metalloproteinase-mediated transforming growth factor-alpha release, thereby activating an epidermal growth factor receptor-dependent cascade culminating, via mitogen-activated protein kinase activation, in specificity protein-1 transactivation of the MUC5AC promoter. RV induction of MUC5AC may be an important mechanism in RV-induced asthma exacerbations in vivo. Revealing the complex serial signalling cascade involved identifies targets for development of pharmacologic intervention to treat mucus hypersecretion in RV-induced illness.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Picornaviridae Infections severityIEP 5131431protein:increased expression:lungRGD 
Picornaviridae Infections severityISOMUC5AC (Homo sapiens)5131431; 5131431protein:increased expression:lungRGD 

Objects Annotated

Genes (Rattus norvegicus)
Muc5ac  (mucin 5AC, oligomeric mucus/gel-forming)

Genes (Mus musculus)
Muc5ac  (mucin 5, subtypes A and C, tracheobronchial/gastric)

Genes (Homo sapiens)
MUC5AC  (mucin 5AC, oligomeric mucus/gel-forming)


Additional Information