RGD Reference Report - Serum KL-6 as a novel disease marker in adolescent and adult cystic fibrosis. - Rat Genome Database

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Serum KL-6 as a novel disease marker in adolescent and adult cystic fibrosis.

Authors: Ohshimo, S  Bonella, F  Grammann, N  Starke, K  Cui, A  Bauer, PC  Teschler, H  Kohno, N  Guzman, J  Costabel, U 
Citation: Ohshimo S, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2009 Jul;26(1):47-53.
RGD ID: 5131272
Pubmed: PMID:19960788   (View Abstract at PubMed)

BACKGROUND: Cystic fibrosis (CF) is a chronic progressive disease leading to obstructive pulmonary impairment, fibrosis and shortened life expectancy. Serum levels of KL-6, high molecular weight human MUC1 mucin, are increased in the majority of patients with various interstitial lung disorders. Whether they are also elevated in CF has not been investigated before. OBJECTIVE: To evaluate whether serum KL-6 levels are elevated and correlate with pulmonary function variables in CF. DESIGN: Serum KL-6, lactate dehydrogenase (LDH) and C-reactive protein (CRP) levels were measured in 72 consecutive CF and 80 age- and sex-matched healthy control subjects. The relationship between serum KL-6 levels and pulmonary function variables was analyzed. RESULTS: Serum KL-6 levels in CF patients were significantly increased compared to healthy subjects. Receiver operating characteristic curve analysis revealed that the diagnostic accuracy of KL-6 was better than that of LDH and CRP. Serum KL-6 levels showed an inverse relationship with vital capacity (VC) % predicted and forced expiratory volume in one second (FEV1) % predicted. CONCLUSIONS: Serum KL-6 levels are elevated and appear to be correlated with pulmonary function variables in CF. These results suggest that KL-6 may be a useful noninvasive marker to monitor disease severity.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cystic fibrosis  IEP 5131272protein:increased expression:serum (human)RGD 
cystic fibrosis  ISOMUC1 (Homo sapiens)5131272; 5131272protein:increased expression:serum (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Muc1  (mucin 1, cell surface associated)

Genes (Mus musculus)
Muc1  (mucin 1, transmembrane)

Genes (Homo sapiens)
MUC1  (mucin 1, cell surface associated)


Additional Information