RGD Reference Report - Cord blood KL-6, a specific lung injury marker, correlates with the subsequent development and severity of atypical bronchopulmonary dysplasia.

General

Cord blood KL-6, a specific lung injury marker, correlates with the subsequent development and severity of atypical bronchopulmonary dysplasia.
Authors:	Kim, DH Kim, HS Shim, SY Lee, JA Choi, CW Kim, EK Kim, BI Choi, JH
Citation:	Kim DH, etal., Neonatology. 2008;93(4):223-9. Epub 2007 Nov 16.
RGD ID:	5131170
Pubmed:	PMID:18025794 (View Abstract at PubMed)
DOI:	DOI:10.1159/111100 (Journal Full-text)
BACKGROUND: A considerable number of preterm infants may have been exposed to inflammation in utero and may be born with an inflamed lung. OBJECTIVES: To determine the impact of antenatal lung injury and inflammatory response on the pathogenesis of bronchopulmonary dysplasia (BPD) according to its clinical pattern, using KL-6 (as a lung injury marker) and C-reactive protein (CRP) (as a marker of inflammatory response). METHODS: In this case-control study, a total of 74 infants (<32 weeks of gestation) including BPD with minimal early lung disease ('atypical'; 21 infants), BPD with significant early lung disease ('classic'; 29 infants) and the non-BPD (24 infants) groups underwent KL-6 and CRP in cord blood determinations. RESULTS: The cord plasma KL-6 levels were significantly higher in the atypical and the total BPD groups than in the non-BPD group (median = 60.9 vs. 34.5 U/ml, p = 0.031; 43.5 vs. 34.5 U/ml, p = 0.02). However, the cord plasma CRP levels were not significantly different among the study groups. The cord plasma KL-6 levels in patients with atypical BPD were significantly higher in infants with moderate or severe BPD than in infants with mild BPD (median = 88.3 vs. 41.5 U/ml, p = 0.041) and were found to be significantly correlated with the duration of oxygen therapy (r = 0.502, p = 0.024). CONCLUSIONS: The present study shows that cord plasma KL-6, a specific lung injury marker, is increased and objectively reflects disease severity in atypical BPD.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
bronchopulmonary dysplasia	severity	IEP		5131170	protein:increased expression:cord plasma	RGD
bronchopulmonary dysplasia	severity	ISO	MUC1 (Homo sapiens)	5131170; 5131170	protein:increased expression:cord plasma	RGD

Objects Annotated

Genes (Rattus norvegicus)

Muc1 (mucin 1, cell surface associated)

Genes (Mus musculus)

Muc1 (mucin 1, transmembrane)

Genes (Homo sapiens)

MUC1 (mucin 1, cell surface associated)

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Cord blood KL-6, a specific lung injury marker, correlates with the subsequent development and severity of atypical bronchopulmonary dysplasia.