RGD Reference Report - Estrogen signaling via estrogen receptor {beta}. - Rat Genome Database

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Estrogen signaling via estrogen receptor {beta}.

Authors: Zhao, C  Dahlman-Wright, K  Gustafsson, JA 
Citation: Zhao C, etal., J Biol Chem. 2010 Dec 17;285(51):39575-9. Epub 2010 Oct 18.
RGD ID: 5130134
Pubmed: PMID:20956532   (View Abstract at PubMed)
PMCID: PMC3000938   (View Article at PubMed Central)
DOI: DOI:10.1074/jbc.R110.180109   (Journal Full-text)

Estrogens act by binding to and activating two estrogen receptors (ERs), ERalpha and ERbeta. Transcriptional regulation by ERs is controlled by a complex array of factors such as ER-ligand binding, the DNA sequence bound by ERs, ER-interacting cofactors, and chromatin context. This minireview will provide an overview of the most recent advances in the identification of ERbeta-regulated target gene networks and ERbeta DNA-binding sites. We also highlight the recent work establishing new roles of ERbeta signaling, including protective functions in the epithelial-mesenchymal transition and in atherosclerosis, as well as regulation of cell proliferation in the colon.


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