RGD Reference Report - Transcriptional control of human p53-regulated genes. - Rat Genome Database

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Transcriptional control of human p53-regulated genes.

Authors: Riley, T  Sontag, E  Chen, P  Levine, A 
Citation: Riley T, etal., Nat Rev Mol Cell Biol. 2008 May;9(5):402-12.
RGD ID: 5129990
Pubmed: PMID:18431400   (View Abstract at PubMed)
DOI: DOI:10.1038/nrm2395   (Journal Full-text)

The p53 protein regulates the transcription of many different genes in response to a wide variety of stress signals. Following DNA damage, p53 regulates key processes, including DNA repair, cell-cycle arrest, senescence and apoptosis, in order to suppress cancer. This Analysis article provides an overview of the current knowledge of p53-regulated genes in these pathways and others, and the mechanisms of their regulation. In addition, we present the most comprehensive list so far of human p53-regulated genes and their experimentally validated, functional binding sites that confer p53 regulation.


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