RGD Reference Report - Role of transforming growth factor Beta in human cancer. - Rat Genome Database

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Role of transforming growth factor Beta in human cancer.

Authors: Elliott, RL  Blobe, GC 
Citation: Elliott RL and Blobe GC, J Clin Oncol. 2005 Mar 20;23(9):2078-93.
RGD ID: 5129811
Pubmed: PMID:15774796   (View Abstract at PubMed)
DOI: DOI:10.1200/JCO.2005.02.047   (Journal Full-text)

Transforming growth factor beta (TGF-beta) is a ubiquitous and essential regulator of cellular and physiologic processes including proliferation, differentiation, migration, cell survival, angiogenesis, and immunosurveillance. Alterations in the TGF-beta signaling pathway, including mutation or deletion of members of the signaling pathway and resistance to TGF-beta-mediated inhibition of proliferation are frequently observed in human cancers. Although these alterations define a tumor suppressor role for the TGF-beta pathway in human cancer, TGF-beta also mediates tumor-promoting effects, either through differential effects on tumor and stromal cells or through a fundamental alteration in the TGF-beta responsiveness of the tumor cells themselves. TGF-beta and members of the TGF-beta signaling pathway are being evaluated as prognostic or predictive markers for cancer patients. Ongoing advances in understanding the TGF-beta signaling pathway will enable targeting of this pathway for the chemoprevention and treatment of human cancers.


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