Notch signaling: control of cell communication and cell fate.

Authors: Lai, EC 
Citation: Lai EC Development. 2004 Mar;131(5):965-73.
Pubmed: (View Article at PubMed) PMID:14973298
DOI: Full-text: DOI:10.1242/dev.01074

Notch is a transmembrane receptor that mediates local cell-cell communication and coordinates a signaling cascade present in all animal species studied to date. Notch signaling is used widely to determine cell fates and to regulate pattern formation; its dysfunction results in a tremendous variety of developmental defects and adult pathologies. This primer describes the mechanism of Notch signal transduction and how it is used to control the formation of biological patterns.

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Additional Information

  
RGD Object Information
RGD ID: 5129787
Created: 2011-04-05
Species: All Species
Last Modified: 2011-04-05
Status: ACTIVE



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