RGD Reference Report - Stats: transcriptional control and biological impact. - Rat Genome Database

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Stats: transcriptional control and biological impact.

Authors: Levy, DE  Darnell JE, JR 
Citation: Levy DE and Darnell JE Jr, Nat Rev Mol Cell Biol. 2002 Sep;3(9):651-62.
RGD ID: 5129754
Pubmed: PMID:12209125   (View Abstract at PubMed)
DOI: DOI:10.1038/nrm909   (Journal Full-text)

Extracellular proteins bound to cell-surface receptors can change nuclear gene expression patterns in minutes, with far-reaching consequences for development, cell growth and homeostasis. The signal transducer and activator of transcription (STAT) proteins are among the most well studied of the latent cytoplasmic signal-dependent transcription-factor pathways. In addition to several roles in normal cell decisions, dysregulation of STAT function contributes to human disease, making the study of these proteins an important topic of current research.


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