RGD Reference Report - Transcriptional regulation by the phosphorylation-dependent factor CREB.

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Transcriptional regulation by the phosphorylation-dependent factor CREB.
Authors:	Mayr, B Montminy, M
Citation:	Mayr B and Montminy M, Nat Rev Mol Cell Biol. 2001 Aug;2(8):599-609.
RGD ID:	5129745
Pubmed:	PMID:11483993 (View Abstract at PubMed)
DOI:	DOI:10.1038/35085068 (Journal Full-text)
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.