RGD Reference Report - Circulating matrix metalloproteinase-9 and osteoporosis in patients with chronic obstructive pulmonary disease. - Rat Genome Database

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Circulating matrix metalloproteinase-9 and osteoporosis in patients with chronic obstructive pulmonary disease.

Authors: Bolton, CE  Stone, MD  Edwards, PH  Duckers, JM  Evans, WD  Shale, DJ 
Citation: Bolton CE, etal., Chron Respir Dis. 2009;6(2):81-7.
RGD ID: 5129553
Pubmed: PMID:19411568   (View Abstract at PubMed)
DOI: DOI:10.1177/1479972309103131   (Journal Full-text)

Matrix metalloproteinase-9 (MMP-9) has been implicated in airways injury in chronic obstructive pulmonary disease (COPD). Osteoporosis is common in patients with COPD, and MMP-9 is an indicator of activated osteoclasts. We hypothesized that circulating MMP-9 would be related to bone mineral density (BMD) in COPD. We explored the relationship between MMP-9, tissue inhibitors of metalloproteinases (TIMP)-1 and -2, and BMD status in patients with COPD. A total of 70 clinically stable patients with confirmed COPD and 39 control subjects underwent spirometry, dual-energy x-ray absorptiometry to determine BMD, and venous sampling for measurement of cytokines and MMP-9 and TIMP-1 and -2. In patients, circulating MMP-9 was increased: mean (SD) 38.5 (2.2) compared with control subjects 20.1 (2.0) ng/mL, P < 0.001, whereas TIMP-1 and -2 were not different. In the patients, MMP-9 was greater in those with osteoporosis, compared with those with osteopenia, no bone disease or control subjects, and patients with osteopenia had greater MMP-9 than control subjects. The adjusted receiver operating characteristics curve area for MMP-9 detecting osteoporosis was 0.86. Patients had elevated systemic inflammatory mediators compared with control subjects, but these were unrelated to bone status. Increased circulating MMP-9 in patients with COPD was related to the presence of osteoporosis and not to lung function. MMP-9 may be a biomarker of increased bone resorption.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
chronic obstructive pulmonary disease  IEP 5129553protein:increased expression:serumRGD 
chronic obstructive pulmonary disease  ISOMMP9 (Homo sapiens)5129553; 5129553protein:increased expression:serumRGD 
osteoporosis  IEP 5129553associated with osteoporosis and protein:increased expression:serumRGD 
osteoporosis  ISOMMP9 (Homo sapiens)5129553; 5129553associated with osteoporosis and protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mmp9  (matrix metallopeptidase 9)

Genes (Mus musculus)
Mmp9  (matrix metallopeptidase 9)

Genes (Homo sapiens)
MMP9  (matrix metallopeptidase 9)


Additional Information