RGD Reference Report - The role of the IKAP gene polymorphisms in atopic diseases in the middle European population. - Rat Genome Database

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The role of the IKAP gene polymorphisms in atopic diseases in the middle European population.

Authors: Schuller, M  Izakovicova Holla, L  Buckova, D  Znojil, V  Stelcl, M  Rybnicek, O  Vacha, J 
Citation: Schuller M, etal., J Hum Genet. 2003;48(6):300-4. Epub 2003 May 28.
RGD ID: 5129158
Pubmed: PMID:12774215   (View Abstract at PubMed)
DOI: DOI:10.1007/s10038-003-0028-0   (Journal Full-text)

Over ten genome-wide screens and many candidate genes studies were performed worldwide to elucidate genetic factors involved in the pathogenesis of bronchial asthma and other atopic diseases. Results from these studies were often discordant, which might have reflected complexity and heterogeneity of these multifactorial diseases. Among a variety of other loci, specific variants of the gene for IKAP (IKK complex-associated protein) were shown to be associated with bronchial asthma in children in a Japanese study. To test the possible role of SNPs in the coding region of the IKAP gene in atopic asthma or other atopic phenotypes in a highly homogenous Czech population, a case-control study including 373 patients and 309 healthy control subjects was performed. There were no significant differences in the genotype and allele distributions for any of five SNPs in the IKAP gene (T819C, G2295A, A2490G, T3214A and C3473T) between patients with atopic asthma or other atopic diseases and healthy controls. These results suggest that the polymorphisms in the coding region of the IKAP gene are unlikely to contribute to atopic disease risk in the Czech population.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
asthma no_associationIAGP 5129158 RGD 
asthma no_associationISOELP1 (Homo sapiens)5129158; 5129158 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Elp1  (elongator acetyltransferase complex subunit 1)

Genes (Mus musculus)
Elp1  (elongator complex protein 1)

Genes (Homo sapiens)
ELP1  (elongator acetyltransferase complex subunit 1)


Additional Information