RGD Reference Report - Lack of association of histamine-N-methyltransferase (HNMT) polymorphisms with asthma in the Indian population. - Rat Genome Database

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Lack of association of histamine-N-methyltransferase (HNMT) polymorphisms with asthma in the Indian population.

Authors: Sharma, S  Mann, D  Singh, TP  Ghosh, B 
Citation: Sharma S, etal., J Hum Genet. 2005;50(12):611-7. Epub 2005 Oct 5.
RGD ID: 5128887
Pubmed: PMID:16205835   (View Abstract at PubMed)
DOI: DOI:10.1007/s10038-005-0302-4   (Journal Full-text)

Histamine plays a major role in allergic disorders, including asthma. A major pathway of histamine biotransformation in the lungs is mediated by histamine N-methyltransferase (HNMT). We investigated the association of a functional SNP C314T; a SNP A929G, a (CA)n repeat in intron 5, and a novel (CA)n repeat (BV677277), 7.5 kb downstream of the HNMT gene with asthma and its associated traits such as total serum IgE levels in a case-control as well as in a family-based study design. In contrast to a previous study, no association was observed for the polymorphisms investigated with asthma (P>0.05). When haplotypes were constructed for these loci and compared, no significant difference was observed in the distribution between cases and controls. In the family-based design, no biased transmission was observed for any of the polymorphisms and haplotypes with asthma using the additive model of inheritance in family-based association test (FBAT). Thus, consistent with the case-control findings, the polymorphisms and haplotypes in the HNMT gene are not associated with asthma in the Indian population.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
asthma no_associationIAGP 5128887 RGD 
asthma no_associationISOHNMT (Homo sapiens)5128887; 5128887 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hnmt  (histamine N-methyltransferase)

Genes (Mus musculus)
Hnmt  (histamine N-methyltransferase)

Genes (Homo sapiens)
HNMT  (histamine N-methyltransferase)


Additional Information