RGD Reference Report - Serum IL-15 in patients with early systemic sclerosis: a potential novel marker of lung disease. - Rat Genome Database

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Serum IL-15 in patients with early systemic sclerosis: a potential novel marker of lung disease.

Authors: Wuttge, DM  Wildt, M  Geborek, P  Wollheim, FA  Scheja, A  Akesson, A 
Citation: Wuttge DM, etal., Arthritis Res Ther. 2007;9(5):R85.
RGD ID: 4974390
Pubmed: PMID:17784951   (View Abstract at PubMed)
PMCID: PMC2212554   (View Article at PubMed Central)
DOI: DOI:10.1186/ar2284   (Journal Full-text)

The pathogenesis of systemic sclerosis (SSc) is characterized by autoimmunity, vasculopathy and fibrosis. IL-15 is a pleiotropic cytokine that has impact on immune, vascular and connective tissue cells. We therefore investigated IL-15 in the circulation of patients with early SSc and explored possible associations of serum IL-15 with vasculopathy and fibrosis. Serum levels of IL-15 were analysed in 63 consecutive patients with SSc of disease duration less than 4 years and without disease-modifying treatment. Thirty-three age-matched healthy control individuals were enrolled. Serum IL-15 levels were increased in the sera of SSc patients compared with that of healthy control individuals (P < 0.01). Serum IL-15 levels correlated with impaired lung function, assessed both by the vital capacity (P < 0.05) and by the carbon monoxide diffusion capacity (P < 0.05). The association between IL-15 and the vital capacity remained after multiple linear regression analysis. Patients with intermediate serum IL-15 levels had a higher prevalence of increased systolic pulmonary pressure compared with patients with either low or high serum IL-15 levels (P < 0.05). Moreover, increased serum IL-15 levels were associated with a reduced nailfold capillary density in multivariable logistic regression analysis (P < 0.01). Serum IL-15 levels also correlated inversely with the systolic blood pressure (P < 0.01). We conclude that IL-15 is associated with fibrotic as well as vascular lung disease and vasculopathy in early SSc. IL-15 may contribute to the pathogenesis of SSc. IL-15 could also be a candidate biomarker for pulmonary involvement and a target for therapy in SSc.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
lung disease  IEP 4974390associated with Scleroderma more ...RGD 
lung disease  ISOIL15 (Homo sapiens)4974390; 4974390associated with Scleroderma more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il15  (interleukin 15)

Genes (Mus musculus)
Il15  (interleukin 15)

Genes (Homo sapiens)
IL15  (interleukin 15)


Additional Information