RGD Reference Report - Interleukin-15 is critical in the pathogenesis of influenza a virus-induced acute lung injury. - Rat Genome Database

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Interleukin-15 is critical in the pathogenesis of influenza a virus-induced acute lung injury.

Authors: Nakamura, R  Maeda, N  Shibata, K  Yamada, H  Kase, T  Yoshikai, Y 
Citation: Nakamura R, etal., J Virol. 2010 Jun;84(11):5574-82. Epub 2010 Mar 24.
RGD ID: 4892670
Pubmed: PMID:20335267   (View Abstract at PubMed)
PMCID: PMC2876592   (View Article at PubMed Central)
DOI: DOI:10.1128/JVI.02030-09   (Journal Full-text)

Highly pathogenic influenza A viruses cause acute severe pneumonia to which the occurrence of "cytokine storm" has been proposed to contribute. Here we show that interleukin-15 (IL-15) knockout (KO) mice exhibited reduced mortality after infection with influenza virus A/FM/1/47 (H1N1, a mouse-adapted strain) albeit the viral titers of these mice showed no difference from those of control mice. There were significantly fewer antigen-specific CD44(+) CD8(+) T cells in the lungs of infected IL-15 KO mice, and adoptive transfer of the CD8(+) T cells caused reduced survival of IL-15 KO mice following influenza virus infection. Mice deficient in beta(2)-microglobulin by gene targeting and those depleted of CD8(+) T cells by in vivo administration of anti-CD8 monoclonal antibody displayed a reduced mortality rate after infection. These results indicate that IL-15-dependent CD8(+) T cells are at least partly responsible for the pathogenesis of acute pneumonia caused by influenza A virus.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
viral pneumonia  ISOIl15 (Mus musculus)4892670; 4892670 RGD 
viral pneumonia  IMP 4892670 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il15  (interleukin 15)

Genes (Mus musculus)
Il15  (interleukin 15)

Genes (Homo sapiens)
IL15  (interleukin 15)


Additional Information