RGD Reference Report - Gene-gene interaction between IL-13 and IL-13Ralpha1 is associated with total IgE in Korean children with atopic asthma. - Rat Genome Database

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Gene-gene interaction between IL-13 and IL-13Ralpha1 is associated with total IgE in Korean children with atopic asthma.

Authors: Kim, HB  Lee, YC  Lee, SY  Jung, J  Jin, HS  Kim, JH  Kim, BS  Kang, MJ  Jang, SO  Kim, J  Kimm, K  Shin, ES  Lee, SG  Hong, SJ 
Citation: Kim HB, etal., J Hum Genet. 2006;51(12):1055-62. Epub 2006 Sep 28.
RGD ID: 4892639
Pubmed: PMID:17006604   (View Abstract at PubMed)
DOI: DOI:10.1007/s10038-006-0061-x   (Journal Full-text)

Interleukin (IL)-13, which is essential for IgE synthesis, mediates its effects by binding with a receptor composed of IL-4Ralpha and IL-13Ralpha1. We investigated the effects of IL-13 and IL-13Ralpha1 polymorphisms in Korean children with asthma, and whether these have been associated with IgE production. We enrolled 358 atopic asthmatic, 111 non-atopic asthmatic, and 146 non-atopic healthy children. IL-13 and IL-13Ralpha1 genotypes were identified using the PCR-RFLP method. There was an association between the asthma susceptibility and homozygosity for risk allele of IL-13 G+2044A. In children with atopic asthma, risk alleles in IL-13 (A-1512C and C-1112T) and IL-13Ralpha1 (A+1398G) showed increased total IgE (P=0.012, 0.015 and 0.017, respectively). Three-loci haplotype analysis for IL-13 showed that the haplotype composed of -1512C, -1112T and +2044A was associated with higher total IgE than other tested haplotypes in children with atopic asthma (P=0.003). The gene-gene interaction between risk alleles of each IL-13 promoter polymorphism and IL-13Ralpha1 polymorphism was associated with higher total IgE in children with atopic asthma (P=0.002, 0.010). These findings indicate that the IL-13 G+2044A is associated with asthma development and the IL-13 and IL-13Ralpha1 polymorphisms may interact to enhance IgE production.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
asthma  IAGP 4892639DNA:polymorphism: :-1512A>C more ...RGD 
asthma  IAGP 4892639DNA:polymorphism: :1398A>G (human)RGD 
asthma  ISOIL13 (Homo sapiens)4892639; 4892639DNA:polymorphism: :-1512A>C more ...RGD 
asthma  ISOIL13RA1 (Homo sapiens)4892639; 4892639DNA:polymorphism: :1398A>G (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il13  (interleukin 13)
Il13ra1  (interleukin 13 receptor subunit alpha 1)

Genes (Mus musculus)
Il13  (interleukin 13)
Il13ra1  (interleukin 13 receptor, alpha 1)

Genes (Homo sapiens)
IL13  (interleukin 13)
IL13RA1  (interleukin 13 receptor subunit alpha 1)


Additional Information