RGD Reference Report - Plasmids encoding the mucosal chemokines CCL27 and CCL28 are effective adjuvants in eliciting antigen-specific immunity in vivo. - Rat Genome Database

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Plasmids encoding the mucosal chemokines CCL27 and CCL28 are effective adjuvants in eliciting antigen-specific immunity in vivo.

Authors: Kutzler, MA  Kraynyak, KA  Nagle, SJ  Parkinson, RM  Zharikova, D  Chattergoon, M  Maguire, H  Muthumani, K  Ugen, K  Weiner, DB 
Citation: Kutzler MA, etal., Gene Ther. 2010 Jan;17(1):72-82. Epub 2009 Oct 22.
RGD ID: 4892196
Pubmed: PMID:19847203   (View Abstract at PubMed)
DOI: DOI:10.1038/gt.2009.112   (Journal Full-text)

A hurdle facing DNA vaccine development is the ability to generate strong immune responses systemically and at local immune sites. We report a novel systemically administered DNA vaccination strategy using intramuscular codelivery of CCL27 or CCL28, which elicited elevated peripheral IFN-gamma and antigen-specific IgG while driving antigen-specific T-cell secretion of cytokine and antibody production in the gut-associated lymphoid tissue and lung. This strategy resulted in induction of long-lived antibody responses that neutralized influenza A/PR8/34 and protected mice from morbidity and mortality associated with a lethal intranasal viral challenge. This is the first example of the use of CCL27 and CCL28 chemokines as adjuvants to influence a DNA vaccine strategy, suggesting further examination of this approach for manipulation of vaccine-induced immunity impacting both quality and phenotype of responses.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Human Influenza resistanceISOCcl28 (Mus musculus)4892196; 4892196 RGD 
Human Influenza resistanceIMP 4892196 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl28  (C-C motif chemokine ligand 28)

Genes (Mus musculus)
Ccl28  (C-C motif chemokine ligand 28)

Genes (Homo sapiens)
CCL28  (C-C motif chemokine ligand 28)


Additional Information