RGD Reference Report - Decreased percentage of CD4+FoxP3+ cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis obliterans syndrome. - Rat Genome Database

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Decreased percentage of CD4+FoxP3+ cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis obliterans syndrome.

Authors: Bhorade, SM  Chen, H  Molinero, L  Liao, C  Garrity, ER  Vigneswaran, WT  Shilling, R  Sperling, A  Chong, A  Alegre, ML 
Citation: Bhorade SM, etal., Transplantation. 2010 Sep 15;90(5):540-6.
RGD ID: 4891471
Pubmed: PMID:20628341   (View Abstract at PubMed)
PMCID: PMC4737704   (View Article at PubMed Central)
DOI: DOI:10.1097/TP.0b013e3181e8dabe   (Journal Full-text)

BACKGROUND: Lung transplantation, in patients with end-stage lung disease, is limited by chronic rejection, which occurs with an incidence and severity exceeding most other transplanted organs. Alloimmune responses play an important role in progression to chronic rejection that manifests as bronchiolitis obliterans syndrome (BOS), but no biomarker can currently predict the progression to BOS. Studies in animal models suggest that intragraft T regulatory cells (Tregs) are important in maintaining transplantation tolerance, and FoxP3 is the protoypic Treg marker. METHODS: Leukocytes in blood and bronchoalveolar lavage (BAL) fluid were compared for expression of FoxP3 by flow cytometry in 14 stable lung transplant recipients and 6 lung transplant recipients who eventually developed BOS. RESULTS: Stable patients, compared with patients who subsequently developed BOS, consistently had a significantly increased percentage of FoxP3 cells among CD4 cells in BAL and greater levels of the Treg-attracting chemokine CCL22. These differences were observed in limited sequential analyses, before, at the time of acute rejection, and postacute rejection. In this pilot study, a threshold of 3.2% CD4/FoxP3 cells in the BAL distinguished stable recipients from those subsequently developing BOS within the first 2 years posttransplantation. CONCLUSION: The proportion of FoxP3 cells among CD4 cells in BAL may help to predict lung allograft outcome and guide therapeutic immunosuppression in lung transplant recipients.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
bronchiolitis obliterans  IEP 4891471 RGD 
bronchiolitis obliterans  ISOCCL22 (Homo sapiens)4891471; 4891471 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl22  (C-C motif chemokine ligand 22)

Genes (Mus musculus)
Ccl22  (C-C motif chemokine ligand 22)

Genes (Homo sapiens)
CCL22  (C-C motif chemokine ligand 22)


Additional Information