RGD Reference Report - Orthodontic force stimulates eNOS and iNOS in rat osteocytes. - Rat Genome Database

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Orthodontic force stimulates eNOS and iNOS in rat osteocytes.

Authors: Tan, SD  Xie, R  Klein-Nulend, J  Van Rheden, RE  Bronckers, AL  Kuijpers-Jagtman, AM  Von den Hoff, JW  Maltha, JC 
Citation: Tan SD, etal., J Dent Res. 2009 Mar;88(3):255-60.
RGD ID: 4891378
Pubmed: PMID:19329460   (View Abstract at PubMed)
DOI: DOI:10.1177/0022034508330861   (Journal Full-text)

Mechanosensitive osteocytes are essential for bone remodeling. Nitric oxide, an important regulator of bone remodeling, is produced by osteocytes through the activity of constitutive endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS). We hypothesized that these enzymes regulate the tissue response to orthodontic force, and therefore we investigated eNOS and iNOS expression in osteocytes during orthodontic force application. The upper rat molars were moved mesially by NiTi coil springs (10 cN, 120 hrs) in a split-mouth design. Immunohistochemical staining revealed that, in the tension area, eNOS-positive osteocytes increased from 24 hrs on, while iNOS-positive osteocytes remained largely constant. In the compression area, iNOS-positive osteocytes increased after 6 hrs, while eNOS- positive osteocytes increased after 24 hrs. This suggests that eNOS mediates bone formation in the tension area, while iNOS mediates inflammation-induced bone resorption in the compression area. Both eNOS and iNOS seem to be important regulators of bone remodeling during orthodontic force application.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to mechanical stimulus  IEP 4891378; 4891378 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nos2  (nitric oxide synthase 2)
Nos3  (nitric oxide synthase 3)


Additional Information