RGD Reference Report - Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A. - Rat Genome Database

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Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A.

Authors: Deken, SL  Beckman, ML  Boos, L  Quick, MW 
Citation: Deken SL, etal., Nat Neurosci. 2000 Oct;3(10):998-1003.
RGD ID: 4891372
Pubmed: PMID:11017172   (View Abstract at PubMed)
DOI: DOI:10.1038/79939   (Journal Full-text)

Plasma membrane GABA transporters participate in neural signaling through re-uptake of neurotransmitter. The domains of the transporter that mediate GABA translocation and regulate transport are not well understood. In the present experiments, the N-terminal cytoplasmic domain of the GABA transporter GAT1 regulated substrate transport rates. This domain directly interacted with syntaxin 1A, a SNARE protein involved in both neurotransmitter release and modulation of calcium channels and cystic fibrosis transmembrane regulator (CFTR) chloride channels. The interaction resulted in a decrease in transporter transport rates. These data demonstrate that intracellular domains of the GABA and protein-protein interactions regulate substrate translocation, and identify a direct link between the machinery involved in transmitter release and re-uptake.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein binding  IPIStx1a (Rattus norvegicus)4891372 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Slc6a1  (solute carrier family 6 member 1)


Additional Information