RGD Reference Report - 5-Lipoxygenase knockout mice exhibit a resistance to pleurisy and lung injury caused by carrageenan. - Rat Genome Database

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5-Lipoxygenase knockout mice exhibit a resistance to pleurisy and lung injury caused by carrageenan.

Authors: Cuzzocrea, S  Rossi, A  Serraino, I  Mazzon, E  Di Paola, R  Dugo, L  Genovese, T  Calabro, B  Caputi, AP  Sautebin, L 
Citation: Cuzzocrea S, etal., J Leukoc Biol. 2003 Jun;73(6):739-46.
RGD ID: 4890419
Pubmed: PMID:12773506   (View Abstract at PubMed)

In the present study, by comparing the responses in wild-type (WT) mice and mice lacking [knockout (KO)] the 5-lipoxygenase (5-LO), we investigated the role played by 5-LO in the development of acute inflammation. When compared with carragenan-treated 5-LOWT mice, 5-LOKO mice, which had received carrageenan, exhibited a reduced degree of pleural exudation, polymorphonuclear cell migration. Lung myeloperoxidase activity, an index of neutrophil infiltration, was significantly reduced in 5-LOKO mice in comparison with 5-LOWT. Lung-tissue sections from carrageenan-treated 5-LOWT mice showed positive staining for intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), P-selectin, and E-selectin, which were mainly localized around vessels. The intensity and degree of ICAM-1, VCAM-1, P-selectin, and E-selectin were markedly reduced in tissue section from carrageenan-5-LOKO mice, which also improved the histological status of the inflamed lungs. Taken together, our results clearly demonstrate that 5-LO modulates neutrophil infiltration in the acute lung inflammation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pleuropneumonia  ISOAlox5 (Mus musculus)4890419; 4890419 RGD 
pleuropneumonia  IMP 4890419 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Alox5  (arachidonate 5-lipoxygenase)

Genes (Mus musculus)
Alox5  (arachidonate 5-lipoxygenase)

Genes (Homo sapiens)
ALOX5  (arachidonate 5-lipoxygenase)


Additional Information