RGD Reference Report - Polymorphisms in the IL-4 and IL-4R genes and allergic asthma. - Rat Genome Database

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Polymorphisms in the IL-4 and IL-4R genes and allergic asthma.

Authors: Cui, T  Wu, J  Pan, S  Xie, J 
Citation: Cui T, etal., Clin Chem Lab Med. 2003 Jul;41(7):888-92.
RGD ID: 4890402
Pubmed: PMID:12940513   (View Abstract at PubMed)
DOI: DOI:10.1515/CCLM.2003.134   (Journal Full-text)

Allergic asthma is caused by genetic and environmental factors that interact to determine disease susceptibility and severity. Several lines of evidence suggest that the interleukin (IL-4 gene and the IL-4-receptor alpha (IL-4Ralpha) gene are involved in the development of atopic diseases. We sought to determine whether two polymorphism sites in IL-4 and IL-4Ralpha chain were associated with allergic asthma in a Chinese population. We obtained DNA and clinical data from allergic asthma patients, which were compared with those of a group of healthy control subjects. The subjects were genotyped for the IL-4 C-590T promoter polymorphism and the IL-4R alpha chain Q576R by polymerase chain reaction-restriction fragment length polymorphism. The results showed that the IL-4 C-590T was not associated with allergic asthma in a Chinese population. However, the IL-4R alpha chain 576R/R was significantly increased in allergic asthma patients compared with control subjects (chi2 = 21.16; p < 0.01), and also total plasma immunoglobulin E (IgE) level was increased in allergic asthma patients. These data suggest that the IL-4R alpha chain 576R/R genotypes confer genetic susceptibility to allergic asthma in Chinese.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
asthma susceptibilityIAGP 4890402DNA:polymorphism:cds:p.Q576R (human)RGD 
asthma susceptibilityISOIL4R (Homo sapiens)4890402; 4890402DNA:polymorphism:cds:p.Q576R (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il4r  (interleukin 4 receptor)

Genes (Mus musculus)
Il4ra  (interleukin 4 receptor, alpha)

Genes (Homo sapiens)
IL4R  (interleukin 4 receptor)


Additional Information