RGD Reference Report - Mannose-binding lectin in severe acute respiratory syndrome coronavirus infection. - Rat Genome Database

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Mannose-binding lectin in severe acute respiratory syndrome coronavirus infection.

Authors: Ip, WK  Chan, KH  Law, HK  Tso, GH  Kong, EK  Wong, WH  To, YF  Yung, RW  Chow, EY  Au, KL  Chan, EY  Lim, W  Jensenius, JC  Turner, MW  Peiris, JS  Lau, YL 
Citation: Ip WK, etal., J Infect Dis. 2005 May 15;191(10):1697-704. Epub 2005 Apr 11.
RGD ID: 4889467
Pubmed: PMID:15838797   (View Abstract at PubMed)
PMCID: PMC7199483   (View Article at PubMed Central)
DOI: DOI:10.1086/429631   (Journal Full-text)

Little is known about the innate immune response to severe acute respiratory syndrome (SARS) coronavirus (CoV) infection. Mannose-binding lectin (MBL), a key molecule in innate immunity, functions as an ante-antibody before the specific antibody response. Here, we describe a case-control study that included 569 patients with SARS and 1188 control subjects and used in vitro assays to investigate the role that MBL plays in SARS-CoV infection. The distribution of MBL gene polymorphisms was significantly different between patients with SARS and control subjects, with a higher frequency of haplotypes associated with low or deficient serum levels of MBL in patients with SARS than in control subjects. Serum levels of MBL were also significantly lower in patients with SARS than in control subjects. There was, however, no association between MBL genotypes, which are associated with low or deficient serum levels of MBL, and mortality related to SARS. MBL could bind SARS-CoV in a dose- and calcium-dependent and mannan-inhibitable fashion in vitro, suggesting that binding is through the carbohydrate recognition domains of MBL. Furthermore, deposition of complement C4 on SARS-CoV was enhanced by MBL. Inhibition of the infectivity of SARS-CoV by MBL in fetal rhesus kidney cells (FRhK-4) was also observed. These results suggest that MBL contributes to the first-line host defense against SARS-CoV and that MBL deficiency is a susceptibility factor for acquisition of SARS.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Coronavirus infectious disease  IAGP 4889467Severe Acute Respiratory Syndrome more ...RGD 
Coronavirus infectious disease  ISOMBL2 (Homo sapiens)4889467; 4889467Severe Acute Respiratory Syndrome more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mbl2  (mannose binding lectin 2)

Genes (Mus musculus)
Mbl2  (mannose-binding lectin (protein C) 2)

Genes (Homo sapiens)
MBL2  (mannose binding lectin 2)


Additional Information