RGD Reference Report - [Association of 5-hydroxytryptamine transporter gene polymorphism with asthma and comorbid depression] - Rat Genome Database

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[Association of 5-hydroxytryptamine transporter gene polymorphism with asthma and comorbid depression]

Authors: Wang, L  Mo, ZC  Wang, Y  Ji, YL 
Citation: Wang L, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009 Oct;26(5):575-9.
RGD ID: 4889460
Pubmed: PMID:19806585   (View Abstract at PubMed)
DOI: DOI:10.3760/cma.j.issn.1003-9406.2009.05.022   (Journal Full-text)

OBJECTIVE: To explore the molecular genetic mechanism of complicating depression in asthma by detecting two gene polymorphisms of 5-hydroxytryptamine transporter (5-HTTLPR/Stin2) gene. METHODS: One hundred fifty-six adults with asthma were collected, and divided into group of asthma with depression (HAMD score > or = 8) and group of asthma without depression or single asthma (HAMD score <8) according to the score of Hamilton depression scale (HAMD). A total of 508 adults with depression alone and 433 healthy individuals were enrolled as controls. The target gene fragments containing the polymorphic regions of 5-HTTLPR and Stin2 were amplified by polymerase chain reaction (PCR). The amplified fragments were then analyzed using agarose gel electrophoresis (AGE) and motored molecular imaging system. RESULTS: The frequencies of genotype and allele distribution of the Stin2 polymorphism showed that males with genotype Stin2.12/Stin2.10 and allele Stin2.10 had higher risk for asthma than the others (Stin2.12/Stin2.10: OR = 2.291, 95% CI: 1.195 and 4.390; Stin2.10: OR = 1.942, 95% CI: 1.069-3.527). No significant difference was found in the frequencies of genotype and allele distribution of the 5-HTTLPR locus between the asthma and healthy control groups and the two stratified by gender. CONCLUSION: The Stin2 polymorphism may play a role in the onset of male asthma. There might be association between the genetic pathogenesis of asthma and depression.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
asthma susceptibilityIAGP 4889460DNA:repeat:intron (human)RGD 
asthma susceptibilityISOSLC6A4 (Homo sapiens)4889460; 4889460DNA:repeat:intron (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Slc6a4  (solute carrier family 6 member 4)

Genes (Mus musculus)
Slc6a4  (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)

Genes (Homo sapiens)
SLC6A4  (solute carrier family 6 member 4)


Additional Information