RGD Reference Report - Association between donor MBL promoter haplotype and graft survival and the development of BOS after lung transplantation. - Rat Genome Database

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Association between donor MBL promoter haplotype and graft survival and the development of BOS after lung transplantation.

Authors: Munster, JM  Van der Bij, W  Breukink, MB  Van der Steege, G  Zuurman, MW  Hepkema, BG  Verschuuren, EA  Van Son, WJ  Seelen, MA 
Citation: Munster JM, etal., Transplantation. 2008 Dec 27;86(12):1857-63.
RGD ID: 4889456
Pubmed: PMID:19104434   (View Abstract at PubMed)
DOI: DOI:10.1097/TP.0b013e31819064b8   (Journal Full-text)

BACKGROUND: Lung transplantation is a well accepted therapy for end-stage lung disease, despite high mortality rates. Mortality after transplantation is mainly caused by allograft failure in the first years after transplantation. Mannose binding lectin (MBL), a recognition molecule of innate immunity, has been associated with transplant outcome in other solid organ transplantation. In this study, the effect of donor- and recipient-MBL genotype on lung transplant outcome was investigated. MATERIALS AND METHODS: All lung transplantations performed in our center, except from retransplantations and combined lung-liver or heart-lung transplantations, were included. Genotyping of the MBL2 variants (promoter: L/H, Y/X, and P/Q allele and exon 1: A/D, A/B, and A/C allele) was performed in donor and recipient DNA. Analyses on graft survival and the development of bronchiolitis obliterans syndrome were performed with Kaplan-Meier (log rank) survival analysis. RESULTS: Of the 277 included cases, DNA was available from 189 donors and 200 recipients and genotyping of the promoter single nucleotide polymorphisms was successful in 184 donors and 198 recipients and of the exon 1 single nucleotide polymorphisms in 181 donors and 193 recipients. Patients who received a graft from a donor with an X-allele had better graft survival (P=0.007) and bronchiolitis obliterans syndrome free survival (P=0.007). Recipient MBL genotype was not associated with transplant outcome. CONCLUSION: The donor X-allele, which corresponds to the LXPA haplotype is associated with superior lung transplant outcome. Our findings might prove to be important in finding ways to optimize outcome after lung transplantation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
bronchiolitis obliterans resistanceIAGP 4889456DNA:transversion:5' utr:-290C>G rs7096206 (human)RGD 
bronchiolitis obliterans resistanceISOMBL2 (Homo sapiens)4889456; 4889456DNA:transversion:5' utr:-290C>G rs7096206 (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mbl2  (mannose binding lectin 2)

Genes (Mus musculus)
Mbl2  (mannose-binding lectin (protein C) 2)

Genes (Homo sapiens)
MBL2  (mannose binding lectin 2)


Additional Information