RGD Reference Report - Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. - Rat Genome Database

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Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity.

Authors: Akbari, O  Stock, P  Meyer, E  Kronenberg, M  Sidobre, S  Nakayama, T  Taniguchi, M  Grusby, MJ  DeKruyff, RH  Umetsu, DT 
Citation: Akbari O, etal., Nat Med. 2003 May;9(5):582-8. Epub 2003 Mar 31.
RGD ID: 4761594
Pubmed: PMID:12669034   (View Abstract at PubMed)
DOI: DOI:10.1038/nm851   (Journal Full-text)

Using natural killer T (NKT) cell-deficient mice, we show here that allergen-induced airway hyperreactivity (AHR), a cardinal feature of asthma, does not develop in the absence of V(alpha)14i NKT cells. The failure of NKT cell-deficient mice to develop AHR is not due to an inability of these mice to produce type 2 T-helper (Th2) responses because NKT cell-deficient mice that are immunized subcutaneously at non-mucosal sites produce normal Th2-biased responses. The failure to develop AHR can be reversed by the adoptive transfer of tetramer-purified NKT cells producing interleukin (IL)-4 and IL-13 to Ja281(-/-) mice, which lack the invariant T-cell receptor (TCR) of NKT cells, or by the administration to Cd1d(-/-) mice of recombinant IL-13, which directly affects airway smooth muscle cells. Thus, pulmonary V(alpha)14i NKT cells crucially regulate the development of asthma and Th2-biased respiratory immunity against nominal exogenous antigens. Therapies that target V(alpha)14i NKT cells may be clinically effective in limiting the development of AHR and asthma.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Bronchial Hyperreactivity  ISOIl13 (Mus musculus)4761594; 4761594 RGD 
Bronchial Hyperreactivity  IDA 4761594 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il13  (interleukin 13)

Genes (Mus musculus)
Il13  (interleukin 13)

Genes (Homo sapiens)
IL13  (interleukin 13)


Additional Information