RGD Reference Report - IL-13 is essential to the late-phase response in allergic rhinitis. - Rat Genome Database

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IL-13 is essential to the late-phase response in allergic rhinitis.

Authors: Miyahara, S  Miyahara, N  Matsubara, S  Takeda, K  Koya, T  Gelfand, EW 
Citation: Miyahara S, etal., J Allergy Clin Immunol. 2006 Nov;118(5):1110-6. Epub 2006 Aug 7.
RGD ID: 4159171
Pubmed: PMID:17088137   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jaci.2006.06.014   (Journal Full-text)

BACKGROUND: The pathophysiology of the early- and late-phase nasal response to allergen challenge is not completely defined. Recent technical advances enable direct monitoring of these responses in mice. OBJECTIVE: IL-13 is detected in the nasal membranes of both human beings and mice with allergic rhinitis, but its role in disease pathogenesis is unclear. We measured early and late nasal allergic responses after treatment with soluble IL-13Ralpha2-IgG fusion protein (sIL-13Ralpha2-Fc), and in IL-13-deficient mice (IL-13(-/-)). METHODS: IL-13(-/-) mice (BALB/c background) and wild-type mice were sensitized to ovalbumin by intraperitoneal injection and then challenged intranasally with ovalbumin without sedation. The sIL-13Ralpha2-Fc or control human IgG was administered by intraperitoneal (i.p.) injection 24 hours and 1 hour before each ovalbumin challenge. Early nasal responses after the 4th ovalbumin challenge and late nasal responses 24 hours after the 6th ovalbumin challenge were assessed. RESULTS: Sensitized/challenged wild-type mice treated with sIL-13Ralpha2-Fc or IL-13(-/-) mice demonstrated significantly reduced late nasal responses in face of persistent nasal tissue eosinophilia; the early nasal response was little affected by targeting IL-13. Goblet cell hyperplasia was not detected in nasal membranes. CONCLUSION: The data indicate that IL-13 is a major contributor to the development of a late nasal response with little influence on the early response, and without affecting nasal eosinophilic inflammation. Inhibition of IL-13 may have an important therapeutic application in preventing the persistent nasal blockage in allergic rhinitis. CLINICAL IMPLICATIONS: Current therapies for allergic rhinitis may not take into account the important differences in the pathophysiology of the early and late responses and the important role of IL-13 in sustaining chronic nasal congestion and obstruction.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
rhinitis disease_progressionISOIl13 (Mus musculus)4159171; 4159171 RGD 
rhinitis  ISOIl13ra2 (Mus musculus)4159171; 4159171 RGD 
rhinitis disease_progressionIMP 4159171 RGD 
rhinitis  IDA 4159171 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il13  (interleukin 13)
Il13ra2  (interleukin 13 receptor subunit alpha 2)

Genes (Mus musculus)
Il13  (interleukin 13)
Il13ra2  (interleukin 13 receptor, alpha 2)

Genes (Homo sapiens)
IL13  (interleukin 13)
IL13RA2  (interleukin 13 receptor subunit alpha 2)


Additional Information