RGD Reference Report - IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome. - Rat Genome Database

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IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome.

Authors: Keane, MP  Gomperts, BN  Weigt, S  Xue, YY  Burdick, MD  Nakamura, H  Zisman, DA  Ardehali, A  Saggar, R  Lynch JP, 3RD  Hogaboam, C  Kunkel, SL  Lukacs, NW  Ross, DJ  Grusby, MJ  Strieter, RM  Belperio, JA 
Citation: Keane MP, etal., J Immunol. 2007 Jan 1;178(1):511-9.
RGD ID: 4146242
Pubmed: PMID:17182591   (View Abstract at PubMed)

Acute allograft rejection is considered to be a predominately type 1 immune mediated response to the donor alloantigen. However, the type 2 immune mediated response has been implicated in multiple fibroproliferative diseases. Based on the fibro-obliterative lesion found during bronchiolitis obliterans syndrome (BOS), we hypothesized that the type 2 immune mediated response is involved in chronic lung allograft rejection. Specifically, whereas acute rejection is, in part, a type 1 immune response, chronic rejection is, in part, a type 2 immune response. We found the type 2 cytokine, IL-13, to be elevated and biologically active in human bronchoalveolar lavage fluid during BOS. Translational studies using a murine model of BOS demonstrated increased expression of IL-13 and its receptors that paralleled fibro-obliteration. In addition, in vivo neutralization of IL-13 reduced airway allograft matrix deposition and murine BOS, by a mechanism that was independent of IL-4. Furthermore, using IL-13Ralpha2(-/-) mice, we found increased fibro-obliteration. Moreover, anti-IL-13 therapy in combination with cyclosporin A had profound effects on reducing murine BOS. This supports the notion that IL-13 biological axis plays an important role during the pathogenesis of BOS independent of the IL-4 biological axis.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Objects Annotated

Genes (Rattus norvegicus)
Il13  (interleukin 13)
Il13ra1  (interleukin 13 receptor subunit alpha 1)
Il13ra2  (interleukin 13 receptor subunit alpha 2)

Genes (Mus musculus)
Il13  (interleukin 13)
Il13ra1  (interleukin 13 receptor, alpha 1)
Il13ra2  (interleukin 13 receptor, alpha 2)

Genes (Homo sapiens)
IL13  (interleukin 13)
IL13RA1  (interleukin 13 receptor subunit alpha 1)
IL13RA2  (interleukin 13 receptor subunit alpha 2)


Additional Information