RGD Reference Report - Expression of endothelin-1 and its receptors in Cisplatin-induced acute renal failure in mice. - Rat Genome Database

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Expression of endothelin-1 and its receptors in Cisplatin-induced acute renal failure in mice.

Authors: Lee, S  Ahn, D 
Citation: Lee S and Ahn D, Korean J Physiol Pharmacol. 2008 Aug;12(4):149-53. Epub 2008 Aug 31.
RGD ID: 4144852
Pubmed: PMID:19967049   (View Abstract at PubMed)
PMCID: PMC2788629   (View Article at PubMed Central)
DOI: DOI:10.4196/kjpp.2008.12.4.149   (Journal Full-text)

Endothelin-1 (ET-1) is unequivocally elevated in the kidney with ischemic acute renal failure (ARF), whereas ET receptors (ET(A)R and ET(B)R) are variably expressed. Although renal functional and structural changes are similar between ischemic and nephrotoxic ARF, there are few reports on the alteration in the ET system in nephrotoxic ARF. This study was, therefore, undertaken to investigate changes in renal expression of ET-1 and its receptors in nephrotoxic ARF induced by cisplatin. Mice were intraperitoneally injected with 16 mg of cisplatin/kg at a single dose, and the expression of mRNA and protein was then quantified by real-time RT-PCR and Western blot, respectively. Immunohistochemistry was conducted for localization. Three days after treatment, ET-1 transcript in cisplatin-treated mice was thirteen times higher than that in controls, whereas ET-1 peptide was increased by 1.5-fold. Cisplatin caused a 2-fold increase in the levels of ET(A)R mRNA and protein. Most of the increased immunoreactive ET-1 and ET(A)R were localized in damaged tubules. Neither the expression of ET(B)R mRNA nor the abundance and immunoreactive level of ET(B)R protein were changed. The findings suggest that the individual components of the renal ET system are differentially regulated in cisplatin-induced nephrotoxic ARF.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
acute kidney failure  ISOEdn1 (Mus musculus)4144852; 4144852mRNA and protein:increased expression:kidney (mouse)RGD 
acute kidney failure  IEP 4144852mRNA and protein:increased expression:kidney (mouse)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Edn1  (endothelin 1)

Genes (Mus musculus)
Edn1  (endothelin 1)

Genes (Homo sapiens)
EDN1  (endothelin 1)


Additional Information