RGD Reference Report - The widespread regulation of microRNA biogenesis, function and decay. - Rat Genome Database

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The widespread regulation of microRNA biogenesis, function and decay.

Authors: Krol, J  Loedige, I  Filipowicz, W 
Citation: Krol J, etal., Nat Rev Genet. 2010 Sep;11(9):597-610. Epub 2010 Jul 27.
RGD ID: 4144851
Pubmed: PMID:20661255   (View Abstract at PubMed)
DOI: DOI:10.1038/nrg2843   (Journal Full-text)

MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression that are approximately 21 nucleotides in length and control many developmental and cellular processes in eukaryotic organisms. Research during the past decade has identified major factors participating in miRNA biogenesis and has established basic principles of miRNA function. More recently, it has become apparent that miRNA regulators themselves are subject to sophisticated control. Many reports over the past few years have reported the regulation of miRNA metabolism and function by a range of mechanisms involving numerous protein-protein and protein-RNA interactions. Such regulation has an important role in the context-specific functions of miRNAs.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

Objects Annotated

Genes (Rattus norvegicus)
Dgcr8  (DGCR8 microprocessor complex subunit)
Dicer1  (dicer 1 ribonuclease III)
Drosha  (drosha ribonuclease III)
Tarbp2  (Tarbp2 subunit of RISC loading complex)

Genes (Mus musculus)
Dgcr8  (DGCR8, microprocessor complex subunit)
Dicer1  (dicer 1, ribonuclease type III)
Drosha  (drosha, ribonuclease type III)
Tarbp2  (TARBP2, RISC loading complex RNA binding subunit)

Genes (Homo sapiens)
DGCR8  (DGCR8 microprocessor complex subunit)
DICER1  (dicer 1, ribonuclease III)
DROSHA  (drosha ribonuclease III)
TARBP2  (TARBP2 subunit of RISC loading complex)


Additional Information