RGD Reference Report - Surfactant protein D regulates airway function and allergic inflammation through modulation of macrophage function. - Rat Genome Database

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Surfactant protein D regulates airway function and allergic inflammation through modulation of macrophage function.

Authors: Takeda, K  Miyahara, N  Rha, YH  Taube, C  Yang, ES  Joetham, A  Kodama, T  Balhorn, AM  Dakhama, A  Duez, C  Evans, AJ  Voelker, DR  Gelfand, EW 
Citation: Takeda K, etal., Am J Respir Crit Care Med. 2003 Oct 1;168(7):783-9. Epub 2003 Jul 25.
RGD ID: 4144051
Pubmed: PMID:12882759   (View Abstract at PubMed)
DOI: DOI:10.1164/rccm.200304-548OC   (Journal Full-text)

The lung collectin surfactant protein D (SP-D) is an important component of the innate immune response but is also believed to play a role in other regulatory aspects of immune and inflammatory responses within the lung. The role of SP-D in the development of allergen-induced airway inflammation and hyperresponsiveness (AHR) is not well defined. SP-D levels progressively increased up to 48 hours after allergen challenge of sensitized mice and then subsequently decreased. The levels of SP-D paralleled the development of airway eosinophilia and AHR. To determine if this association was functionally relevant, mice were administered rat SP-D (rSP-D) intratracheally. When given to sensitized mice before challenge, AHR and eosinophilia were reduced by rSP-D in a dose-dependent manner but not by mutant rSP-D. rSP-D administration resulted in increased levels of interleukin (IL)-10, IL-12, and IFN-gamma in bronchoalveolar lavage fluid and reduced goblet cell hyperplasia. Culture of alveolar macrophages together with SP-D and allergen resulted in increased production of IL-10, IL-12, and IFN-gamma. These results indicate that SP-D can (negatively) regulate the development of AHR and airway inflammation after airway challenge of sensitized mice, at least in part, by modulating the function of alveolar macrophages.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Bronchial Hyperreactivity  ISOSftpd (Rattus norvegicus)4144051; 4144051 RGD 
Bronchial Hyperreactivity  IDA 4144051 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Sftpd  (surfactant protein D)

Genes (Mus musculus)
Sftpd  (surfactant associated protein D)

Genes (Homo sapiens)
SFTPD  (surfactant protein D)


Additional Information