RGD Reference Report - Activities of enzymes of acetoacetate metabolism in rat brown adipose tissue during development. - Rat Genome Database

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Activities of enzymes of acetoacetate metabolism in rat brown adipose tissue during development.

Authors: Williamson, DH  Ilic, V 
Citation: Williamson DH and Ilic V, Biochem J. 1985 Nov 1;231(3):773-5.
RGD ID: 2326101
Pubmed: PMID:2866764   (View Abstract at PubMed)
PMCID: PMC1152816   (View Article at PubMed Central)

The activities of two mitochondrial enzymes concerned in the utilization of acetoacetate, namely 3-oxoacid CoA-transferase and acetoacetyl-CoA thiolase, were high throughout the suckling and weanling period in brown adipose tissue of the rat. In contrast, 3-hydroxybutyrate dehydrogenase activity was comparatively low during this period. The activity of cytosolic acetoacetyl-CoA synthetase (involved in lipogenesis) declined after birth and remained low until the pups were weaned. Experiments with brown-adipose-tissue slices from weanling rats indicated that 70% of the [3-14C]acetoacetate utilized was oxidized to 14CO2, and this value was not altered appreciably by the addition of glucose and insulin.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
adipose tissue development  IEP 2326101; 2326101; 2326101 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Acat1  (acetyl-CoA acetyltransferase 1)
Bdh1  (3-hydroxybutyrate dehydrogenase 1)
Oxct1  (3-oxoacid CoA transferase 1)


Additional Information