RGD Reference Report - Ocular inflammation alters swelling and membrane characteristics of rat Muller glial cells. - Rat Genome Database

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Ocular inflammation alters swelling and membrane characteristics of rat Muller glial cells.

Authors: Pannicke, T  Uckermann, O  Iandiev, I  Wiedemann, P  Reichenbach, A  Bringmann, A 
Citation: Pannicke T, etal., J Neuroimmunol. 2005 Apr;161(1-2):145-54.
RGD ID: 2326045
Pubmed: PMID:15748953   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jneuroim.2005.01.003   (Journal Full-text)

Ocular inflammation is a common cause of retinal edema that may involve swelling of Muller glial cells. In order to investigate whether endotoxin-induced ocular inflammation in rats alters the swelling and membrane characteristics of Muller cells, lipopolysaccharide (LPS; 0.5%) was intravitreally injected. At 3 and 7 days after treatment, hypotonic challenge induced swelling of Muller cell somata that was not observed in non-treated control eyes. Muller cells of LPS-treated eyes displayed a downregulation of inward K(+) currents and upregulation of A-type K(+) currents that was associated with a decreased expression of Kir4.1 protein in retinal slices. The data suggest that ocular inflammation induces alterations of both the swelling characteristics and the K(+) channel expression of Muller cells.

Objects referenced in this article
Gene Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 Rattus norvegicus

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